Replanning Criteria and Timing Definition for Parotid Protection-Based Adaptive Radiation Therapy in Nasopharyngeal Carcinoma
Joint Authors
Feng, Lin-Chun
Yao, Wei-Rong
Liu, Bo
Cao, Xiu-Tang
Ren, Gang
Du, Lei
Zhou, Fu-Gen
Qu, Bao-Lin
Xie, Chuan-Bin
Xu, Shou-Ping
Ma, Lin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The goal of this study was to evaluate real-time volumetric and dosimetric changes of the parotid gland so as to determine replanning criteria and timing for parotid protection-based adaptive radiation therapy in nasopharyngeal carcinoma.
Fifty NPC patients were treated with helical tomotherapy; volumetric and dosimetric ( D m e a n , V 1 , and D 50 ) changes of the parotid gland at the 1st, 6th, 11th, 16th, 21st, 26th, 31st, and 33rd fractions were evaluated.
The clinical parameters affecting these changes were studied by analyses of variance methods for repeated measures.
Factors influencing the actual parotid dose were analyzed by a multivariate logistic regression model.
The cut-off values predicting parotid overdose were developed from receiver operating characteristic curves and judged by combining them with a diagnostic test consistency check.
The median absolute value and percentage of parotid volume reduction were 19.51 cm3 and 35%, respectively.
The interweekly parotid volume varied significantly ( p < 0.05 ).
The parotid D m e a n , V 1 , and D 50 increased by 22.13%, 39.42%, and 48.45%, respectively.
The actual parotid dose increased by an average of 11.38% at the end of radiation therapy.
Initial parotid volume, initial parotid D m e a n , and weight loss rate are valuable indicators for parotid protection-based replanning.
American Psychological Association (APA)
Yao, Wei-Rong& Xu, Shou-Ping& Liu, Bo& Cao, Xiu-Tang& Ren, Gang& Du, Lei…[et al.]. 2015. Replanning Criteria and Timing Definition for Parotid Protection-Based Adaptive Radiation Therapy in Nasopharyngeal Carcinoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055622
Modern Language Association (MLA)
Yao, Wei-Rong…[et al.]. Replanning Criteria and Timing Definition for Parotid Protection-Based Adaptive Radiation Therapy in Nasopharyngeal Carcinoma. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055622
American Medical Association (AMA)
Yao, Wei-Rong& Xu, Shou-Ping& Liu, Bo& Cao, Xiu-Tang& Ren, Gang& Du, Lei…[et al.]. Replanning Criteria and Timing Definition for Parotid Protection-Based Adaptive Radiation Therapy in Nasopharyngeal Carcinoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055622
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055622