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Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms
Joint Authors
Yap, Ning Yi
Rajandram, Retnagowri
Ng, Keng Lim
Pailoor, Jayalakshmi
Fadzli, Ahmad
Gobe, Glenda C.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-13
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Abstract EN
The most common form of malignant renal neoplasms is renal cell carcinoma (RCC), which is classified into several different subtypes based on the histomorphological features.
However, overlaps in these characteristics may present difficulties in the accurate diagnosis of these subtypes, which have different clinical outcomes.
Genomic and molecular studies have revealed unique genetic aberrations in each subtype.
Knowledge of these genetic changes in hereditary and sporadic renal neoplasms has given an insight into the various proteins and signalling pathways involved in tumour formation and progression.
In this review, the genetic aberrations characteristic to each renal neoplasm subtype are evaluated along with the associated protein products and affected pathways.
The potential applications of these genetic aberrations and proteins as diagnostic tools, prognostic markers, or therapeutic targets are also assessed.
American Psychological Association (APA)
Yap, Ning Yi& Rajandram, Retnagowri& Ng, Keng Lim& Pailoor, Jayalakshmi& Fadzli, Ahmad& Gobe, Glenda C.. 2015. Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms. BioMed Research International،Vol. 2015, no. 2015, pp.1-22.
https://search.emarefa.net/detail/BIM-1055623
Modern Language Association (MLA)
Yap, Ning Yi…[et al.]. Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms. BioMed Research International No. 2015 (2015), pp.1-22.
https://search.emarefa.net/detail/BIM-1055623
American Medical Association (AMA)
Yap, Ning Yi& Rajandram, Retnagowri& Ng, Keng Lim& Pailoor, Jayalakshmi& Fadzli, Ahmad& Gobe, Glenda C.. Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-22.
https://search.emarefa.net/detail/BIM-1055623
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055623