Serum Levels of ApoA1 and ApoA2 Are Associated with Cognitive Status in Older Men
Joint Authors
Ma, Cheng
Li, Jin
Bao, Zhijun
Ruan, Qingwei
Yu, Zhuowei
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Advancing age, chronic inflammation, oxidative damage, and disorders of lipid metabolism are positively linked to the late-life cognitive impairment.
Serum biomarkers may be associated with the cognitive status in older men.
Methods.
440 old male subjects with different cognitive functions were recruited to investigate probable serum markers.
Pearson Chi-Squared test, univariate analysis, and multivariate logistic regression analysis were performed to evaluate biomarkers which may be associated with cognitive status.
Results.
Levels of fundus atherosclerosis (AS) ( P < 0.001 ), age ( P < 0.001 ), serum biomarkers peroxidase (POD) ( P = 0.026 ) and interleukin-6 (IL-6) ( P = 0.001 ), serum levels of high-density lipoprotein cholesterol (HDL-C) ( P < 0.001 ), apolipoprotein A2 (ApoA2) ( P = 0.001 ), and ApoC2 ( P = 0.005 ) showed significant differences.
Compared to group 3, ApoA1 in group 1 (OR = 1.30, 95% CI 1.01–1.67) and group 2 (OR = 1.47, 95% CI 1.11–1.94) were higher, while ApoA2 were lower (group 1: OR = 0.43, 95% CI 0.18–1.02; group 2: OR = 0.21, 95% CI 0.08–0.54) after adjusting for control variables.
Conclusion.
The results demonstrated that age, AS levels, POD, IL-6, HDL-C, ApoA2, and ApoC2 were significantly related to cognitive status.
Moreover, ApoA1 and ApoA2 were independently associated with cognitive impairment and late-life dementia.
American Psychological Association (APA)
Ma, Cheng& Li, Jin& Bao, Zhijun& Ruan, Qingwei& Yu, Zhuowei. 2015. Serum Levels of ApoA1 and ApoA2 Are Associated with Cognitive Status in Older Men. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055639
Modern Language Association (MLA)
Bao, Zhijun…[et al.]. Serum Levels of ApoA1 and ApoA2 Are Associated with Cognitive Status in Older Men. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1055639
American Medical Association (AMA)
Ma, Cheng& Li, Jin& Bao, Zhijun& Ruan, Qingwei& Yu, Zhuowei. Serum Levels of ApoA1 and ApoA2 Are Associated with Cognitive Status in Older Men. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055639
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055639