Bypassing P-Glycoprotein Drug Efflux Mechanisms: Possible Applications in Pharmacoresistant Schizophrenia Therapy
Joint Authors
du Toit, Lisa C.
Pillay, Viness
Tyagi, Charu
Tomar, Lomas K.
Hoosain, Famida G.
Choonara, Yahya E.
Kumar, Pradeep
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-27
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
The efficient noninvasive treatment of neurodegenerative disorders is often constrained by reduced permeation of therapeutic agents into the central nervous system (CNS).
A vast majority of bioactive agents do not readily permeate into the brain tissue due to the existence of the blood-brain barrier (BBB) and the associated P-glycoprotein efflux transporter.
The overexpression of the MDR1 P-glycoprotein has been related to the occurrence of multidrug resistance in CNS diseases.
Various research outputs have focused on overcoming the P-glycoprotein drug efflux transporter, which mainly involve its inhibition or bypassing mechanisms.
Studies into neurodegenerative disorders have shown that the P-glycoprotein efflux transporter plays a vital role in the progression of schizophrenia, with a noted increase in P-glycoprotein function among schizophrenic patients, thereby reducing therapeutic outcomes.
In this review, we address the hypothesis that methods employed in overcoming P-glycoprotein in cancer and other disease states at the level of the BBB and intestine may be applied to schizophrenia drug delivery system design to improve clinical efficiency of drug therapies.
In addition, the current review explores polymers and drug delivery systems capable of P-gp inhibition and modulation.
American Psychological Association (APA)
Hoosain, Famida G.& Choonara, Yahya E.& Tomar, Lomas K.& Kumar, Pradeep& Tyagi, Charu& du Toit, Lisa C.…[et al.]. 2015. Bypassing P-Glycoprotein Drug Efflux Mechanisms: Possible Applications in Pharmacoresistant Schizophrenia Therapy. BioMed Research International،Vol. 2015, no. 2015, pp.1-21.
https://search.emarefa.net/detail/BIM-1055655
Modern Language Association (MLA)
Hoosain, Famida G.…[et al.]. Bypassing P-Glycoprotein Drug Efflux Mechanisms: Possible Applications in Pharmacoresistant Schizophrenia Therapy. BioMed Research International No. 2015 (2015), pp.1-21.
https://search.emarefa.net/detail/BIM-1055655
American Medical Association (AMA)
Hoosain, Famida G.& Choonara, Yahya E.& Tomar, Lomas K.& Kumar, Pradeep& Tyagi, Charu& du Toit, Lisa C.…[et al.]. Bypassing P-Glycoprotein Drug Efflux Mechanisms: Possible Applications in Pharmacoresistant Schizophrenia Therapy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-21.
https://search.emarefa.net/detail/BIM-1055655
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055655