Prognostic Significance of Serum Inflammatory Response Markers in Newly Diagnosed Non-Small Cell Lung Cancer before Chemoirradiation

Abstract EN

Purpose.

To identify whether the serum’s baseline C-reactive protein (CRP) and albumin (Alb) levels related to clinicopathological parameters and overall survival (OS) in non-small cell lung cancer (NSCLC).

Methods.

In total, 100 consecutive patients (mean age = 68.38 ± 10.85 years) that underwent chemoradiotherapy were studied.

Measurements of CRP and Alb were performed before any treatment.

Results.

Serum CRP levels were significantly associated with histological grade ( P < 0.001 ) , TNM stage ( P < 0.001 ) , PS ( P = 0.009 ) , and Alb ( P < 0.001 ) .

Additionally CRP and Alb levels were found significantly associated with overall survival in univariate analysis (log-rank test, P < 0.001 and P = 0.002 , resp.) and CRP remained significant after controlling for age, alcohol, performance status, and TNM stage, whereas albumin showed a borderline effect on the hazard rate ( P = 0.052 ) .

Conclusions.

CRP and Alb are both promising biomarkers in identification of NSCLC patients with poor prognosis and form a possible target for intensifying their therapies.