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Arctigenin, a Potent Ingredient of Arctium lappa L., Induces Endothelial Nitric Oxide Synthase and Attenuates Subarachnoid Hemorrhage-Induced Vasospasm through PI3KAkt Pathway in a Rat Model
Joint Authors
Lin, Chih-Lung
Chang, Chih-Zen
Wu, Shu-Chuan
Kwan, Aij-Lie
Chang, Chia-Mao
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Upregulation of protein kinase B (PKB, also known as Akt) is observed within the cerebral arteries of subarachnoid hemorrhage (SAH) animals.
This study is of interest to examine Arctigenin, a potent antioxidant, on endothelial nitric oxide synthase (eNOS) and Akt pathways in a SAH in vitro study.
Basilar arteries (BAs) were obtained to examine phosphatidylinositol-3-kinase (PI3K), phospho-PI3K, Akt, phospho-Akt (Western blot) and morphological examination.
Endothelins (ETs) and eNOS evaluation (Western blot and immunostaining) were also determined.
Arctigenin treatment significantly alleviates disrupted endothelial cells and tortured internal elastic layer observed in the SAH groups (p<0.01).
The reduced eNOS protein and phospho-Akt expression in the SAH groups were relieved by the treatment of Arctigenin (p<0.01).
This result confirmed that Arctigenin might exert dural effects in preventing SAH-induced vasospasm through upregulating eNOS expression via the PI3K/Akt signaling pathway and attenuate endothelins after SAH.
Arctigenin shows therapeutic promise in the treatment of cerebral vasospasm following SAH.
American Psychological Association (APA)
Chang, Chih-Zen& Wu, Shu-Chuan& Chang, Chia-Mao& Lin, Chih-Lung& Kwan, Aij-Lie. 2015. Arctigenin, a Potent Ingredient of Arctium lappa L., Induces Endothelial Nitric Oxide Synthase and Attenuates Subarachnoid Hemorrhage-Induced Vasospasm through PI3KAkt Pathway in a Rat Model. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055676
Modern Language Association (MLA)
Chang, Chih-Zen…[et al.]. Arctigenin, a Potent Ingredient of Arctium lappa L., Induces Endothelial Nitric Oxide Synthase and Attenuates Subarachnoid Hemorrhage-Induced Vasospasm through PI3KAkt Pathway in a Rat Model. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1055676
American Medical Association (AMA)
Chang, Chih-Zen& Wu, Shu-Chuan& Chang, Chia-Mao& Lin, Chih-Lung& Kwan, Aij-Lie. Arctigenin, a Potent Ingredient of Arctium lappa L., Induces Endothelial Nitric Oxide Synthase and Attenuates Subarachnoid Hemorrhage-Induced Vasospasm through PI3KAkt Pathway in a Rat Model. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055676
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055676