Disturbance of Oligodendrocyte Function Plays a Key Role in the Pathogenesis of Schizophrenia and Major Depressive Disorder
Joint Authors
Miyata, Shingo
Hattori, Tsuyoshi
Shimizu, Shoko
Ito, Akira
Tohyama, Masaya
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-26, 26 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-01
Country of Publication
Egypt
No. of Pages
26
Main Subjects
Abstract EN
The major psychiatric disorders such as schizophrenia (SZ) and major depressive disorder (MDD) are thought to be multifactorial diseases related to both genetic and environmental factors.
However, the genes responsible and the molecular mechanisms underlying the pathogenesis of SZ and MDD remain unclear.
We previously reported that abnormalities of disrupted-in-Schizophrenia-1 (DISC1) and DISC1 binding zinc finger (DBZ) might cause major psychiatric disorders such as SZ.
Interestingly, both DISC and DBZ have been further detected in oligodendrocytes and implicated in regulating oligodendrocyte differentiation.
DISC1 negatively regulates the differentiation of oligodendrocytes, whereas DBZ plays a positive regulatory role in oligodendrocyte differentiation.
We have reported that repeated stressful events, one of the major risk factors of MDD, can induce sustained upregulation of plasma corticosterone levels and serum/glucocorticoid regulated kinase 1 (Sgk1) mRNA expression in oligodendrocytes.
Repeated stressful events can also activate the SGK1 cascade and cause excess arborization of oligodendrocyte processes, which is thought to be related to depressive-like symptoms.
In this review, we discuss the expression of DISC1, DBZ, and SGK1 in oligodendrocytes, their roles in the regulation of oligodendrocyte function, possible interactions of DISC1 and DBZ in relation to SZ, and the activation of the SGK1 signaling cascade in relation to MDD.
American Psychological Association (APA)
Miyata, Shingo& Hattori, Tsuyoshi& Shimizu, Shoko& Ito, Akira& Tohyama, Masaya. 2015. Disturbance of Oligodendrocyte Function Plays a Key Role in the Pathogenesis of Schizophrenia and Major Depressive Disorder. BioMed Research International،Vol. 2015, no. 2015, pp.1-26.
https://search.emarefa.net/detail/BIM-1055687
Modern Language Association (MLA)
Miyata, Shingo…[et al.]. Disturbance of Oligodendrocyte Function Plays a Key Role in the Pathogenesis of Schizophrenia and Major Depressive Disorder. BioMed Research International No. 2015 (2015), pp.1-26.
https://search.emarefa.net/detail/BIM-1055687
American Medical Association (AMA)
Miyata, Shingo& Hattori, Tsuyoshi& Shimizu, Shoko& Ito, Akira& Tohyama, Masaya. Disturbance of Oligodendrocyte Function Plays a Key Role in the Pathogenesis of Schizophrenia and Major Depressive Disorder. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-26.
https://search.emarefa.net/detail/BIM-1055687
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055687