Expression Profile of Sonic Hedgehog Pathway Members in the Developing Human Fetal Brain
Joint Authors
Harter, Patrick N.
Mittelbronn, Michel
Tichy, Julia
Zinke, Jenny
Bunz, Benedikt
Meyermann, Richard
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-21
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The Sonic Hedgehog (SHH) pathway plays a central role in the developing mammalian CNS.
In our study, we aimed to investigate the spatiotemporal SHH pathway expression pattern in human fetal brains.
We analyzed 22 normal fetal brains for Shh, Patched, Smoothened, and Gli1-3 expression by immunohistochemistry.
In the telencephalon, strongest expression of Shh, Smoothened, and Gli2 was found in the cortical plate (CP) and ventricular zone.
Patched was strongly upregulated in the ventricular zone and Gli1 in the CP.
In the cerebellum, SHH pathway members were strongly expressed in the external granular layer (EGL).
SHH pathway members significantly decreased over time in the ventricular and subventricular zone and in the cerebellar EGL, while increasing levels were found in more superficial telencephalic layers.
Our findings show that SHH pathway members are strongly expressed in areas important for proliferation and differentiation and indicate a temporal expression gradient in telencephalic and cerebellar layers probably due to decreased proliferation of progenitor cells and increased differentiation.
Our data about the spatiotemporal expression of SHH pathway members in the developing human brain serves as a base for the understanding of both normal and pathological CNS development.
American Psychological Association (APA)
Tichy, Julia& Zinke, Jenny& Bunz, Benedikt& Meyermann, Richard& Harter, Patrick N.& Mittelbronn, Michel. 2015. Expression Profile of Sonic Hedgehog Pathway Members in the Developing Human Fetal Brain. BioMed Research International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1055695
Modern Language Association (MLA)
Tichy, Julia…[et al.]. Expression Profile of Sonic Hedgehog Pathway Members in the Developing Human Fetal Brain. BioMed Research International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1055695
American Medical Association (AMA)
Tichy, Julia& Zinke, Jenny& Bunz, Benedikt& Meyermann, Richard& Harter, Patrick N.& Mittelbronn, Michel. Expression Profile of Sonic Hedgehog Pathway Members in the Developing Human Fetal Brain. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1055695
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055695