Biological and Pharmacological Aspects of the NK1-Receptor
Joint Authors
Garcia-Recio, Susana
Gascón, Pedro
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-03
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The neurokinin 1 receptor (NK-1R) is the main receptor for the tachykinin family of peptides.
Substance P (SP) is the major mammalian ligand and the one with the highest affinity.
SP is associated with multiple processes: hematopoiesis, wound healing, microvasculature permeability, neurogenic inflammation, leukocyte trafficking, and cell survival.
It is also considered a mitogen, and it has been associated with tumorigenesis and metastasis.
Tachykinins and their receptors are widely expressed in various human systems such as the nervous, cardiovascular, genitourinary, and immune system.
Particularly, NK-1R is found in the nervous system and in peripheral tissues and are involved in cellular responses such as pain transmission, endocrine and paracrine secretion, vasodilation, and modulation of cell proliferation.
It also acts as a neuromodulator contributing to brain homeostasis and to sensory neuronal transmission associated with depression, stress, anxiety, and emesis.
NK-1R and SP are present in brain regions involved in the vomiting reflex (the nucleus tractus solitarius and the area postrema).
This anatomical localization has led to the successful clinical development of antagonists against NK-1R in the treatment of chemotherapy-induced nausea and vomiting (CINV).
The first of these antagonists, aprepitant (oral administration) and fosaprepitant (intravenous administration), are prescribed for high and moderate emesis.
American Psychological Association (APA)
Garcia-Recio, Susana& Gascón, Pedro. 2015. Biological and Pharmacological Aspects of the NK1-Receptor. BioMed Research International،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1055697
Modern Language Association (MLA)
Garcia-Recio, Susana& Gascón, Pedro. Biological and Pharmacological Aspects of the NK1-Receptor. BioMed Research International No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1055697
American Medical Association (AMA)
Garcia-Recio, Susana& Gascón, Pedro. Biological and Pharmacological Aspects of the NK1-Receptor. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1055697
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055697