Dopamine D2 Receptor Is Involved in Alleviation of Type II Collagen-Induced Arthritis in Mice
Joint Authors
Lu, Jian-Hua
Liu, Yi-Qian
Deng, Qiao-Wen
Peng, Yu-Ping
Qiu, Yi-Hua
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Human and murine lymphocytes express dopamine (DA) D2-like receptors including DRD2, DRD3, and DRD4.
However, their roles in rheumatoid arthritis (RA) are less clear.
Here we showed that lymphocyte DRD2 activation alleviates both imbalance of T-helper (Th)17/T-regulatory (Treg) cells and inflamed symptoms in a mouse arthritis model of RA.
Collagen-induced arthritis (CIA) was prepared by intradermal injection of chicken collagen type II (CII) in tail base of DBA/1 mice or Drd2 −/− C57BL/6 mice.
D2-like receptor agonist quinpirole downregulated expression of proinflammatory Th17-related cytokines interleukin- (IL-) 17 and IL-22 but further upregulated expression of anti-inflammatory Treg-related cytokines transforming growth factor- (TGF-) β and IL-10 in lymphocytes in vitro and in ankle joints in vivo in CIA mice.
Quinpirole intraperitoneal administration reduced both clinical arthritis score and serum anti-CII IgG level in CIA mice.
However, Drd2 −/− CIA mice manifested more severe limb inflammation and higher serum anti-CII IgG level and further upregulated IL-17 and IL-22 expression and downregulated TGF-β and IL-10 expression than wild-type CIA mice.
In contrast, Drd1 −/− CIA mice did not alter limb inflammation or anti-CII IgG level compared with wild-type CIA mice.
These results suggest that DRD2 activation is involved in alleviation of CIA symptoms by amelioration of Th17/Treg imbalance.
American Psychological Association (APA)
Lu, Jian-Hua& Liu, Yi-Qian& Deng, Qiao-Wen& Peng, Yu-Ping& Qiu, Yi-Hua. 2015. Dopamine D2 Receptor Is Involved in Alleviation of Type II Collagen-Induced Arthritis in Mice. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055701
Modern Language Association (MLA)
Lu, Jian-Hua…[et al.]. Dopamine D2 Receptor Is Involved in Alleviation of Type II Collagen-Induced Arthritis in Mice. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055701
American Medical Association (AMA)
Lu, Jian-Hua& Liu, Yi-Qian& Deng, Qiao-Wen& Peng, Yu-Ping& Qiu, Yi-Hua. Dopamine D2 Receptor Is Involved in Alleviation of Type II Collagen-Induced Arthritis in Mice. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055701
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055701