Phase II, Open Label, Randomized Comparative Trial of Ondansetron Alone versus the Combination of Ondansetron and Aprepitant for the Prevention of Nausea and Vomiting in Patients with Hematologic Malignancies Receiving Regimens Containing High-Dose Cytarabine
Joint Authors
Badar, Talha
Cortes, Jorge
Borthakur, Gautam
O’Brien, Susan
Wierda, William
Garcia-Manero, Guillermo
Ferrajoli, Alessandra
Kadia, Tapan
Poku, Rebeca
Kantarjian, Hagop
Mattiuzzi, Gloria
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Aprepitant is a P/neurokinin-1 receptor antagonist approved for the prevention of CINV in moderate emetic risk chemotherapy.
We explored its effectiveness in patients with leukemia receiving cytarabine-based chemotherapy.
Methods.
Patients were randomized to ondansetron (OND) 8 mg IV 30 minutes before cytarabine followed by 24 mg IV continuous infusion daily until 6–12 hours after the last dose of chemotherapy alone or with aprepitant (APREP) oral 125 mg 6–12 hrs before chemotherapy and 80 mg daily until 1 day after the last dose of chemotherapy.
Results.
Forty-nine patients were enrolled in each arm; 42 in OND and 41 in OND + APREP arm were evaluable for efficacy.
The ORR with OND + APREP was 80% compared to 67% with OND alone (P=0.11).
On days 6 and 7, higher proportion of patients treated with OND + APREP were free from nausea (74%, 74% versus 68%, 67%; P=0.27 and 0.18, resp.).
Requirement of rescue medications on days 2 and 3 was fewer in OND + APREP arm 7% and 5% compared to 21% and 16% in the OND arm, respectively (P=0.06 and P=0.07).
Conclusions.
There was a trend for overall improvement in emesis with ondansetron plus aprepitant.
The potential benefit of this approach with specific chemotherapy combinations remains to be determined.
American Psychological Association (APA)
Badar, Talha& Cortes, Jorge& Borthakur, Gautam& O’Brien, Susan& Wierda, William& Garcia-Manero, Guillermo…[et al.]. 2015. Phase II, Open Label, Randomized Comparative Trial of Ondansetron Alone versus the Combination of Ondansetron and Aprepitant for the Prevention of Nausea and Vomiting in Patients with Hematologic Malignancies Receiving Regimens Containing High-Dose Cytarabine. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055704
Modern Language Association (MLA)
Badar, Talha…[et al.]. Phase II, Open Label, Randomized Comparative Trial of Ondansetron Alone versus the Combination of Ondansetron and Aprepitant for the Prevention of Nausea and Vomiting in Patients with Hematologic Malignancies Receiving Regimens Containing High-Dose Cytarabine. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1055704
American Medical Association (AMA)
Badar, Talha& Cortes, Jorge& Borthakur, Gautam& O’Brien, Susan& Wierda, William& Garcia-Manero, Guillermo…[et al.]. Phase II, Open Label, Randomized Comparative Trial of Ondansetron Alone versus the Combination of Ondansetron and Aprepitant for the Prevention of Nausea and Vomiting in Patients with Hematologic Malignancies Receiving Regimens Containing High-Dose Cytarabine. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055704
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055704