Second Surgery in Insular Low-Grade Gliomas
Joint Authors
Cesselli, Daniela
De Maglio, Giovanna
Ius, Tamara
Pauletto, Giada
Isola, Miriam
Turella, Luca
Budai, Riccardo
Eleopra, Roberto
Fadiga, Luciano
Lettieri, Christian
Pizzolitto, Stefano
Beltrami, Carlo Alberto
Skrap, Miran
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Given the technical difficulties, a limited number of works have been published on insular gliomas surgery and risk factors for tumor recurrence (TR) are poorly documented.
Objective.
The aim of the study was to determine TR in adult patients with initial diagnosis of insular Low-Grade Gliomas (LGGs) that subsequently underwent second surgery.
Methods.
A consecutive series of 53 patients with insular LGGs was retrospectively reviewed; 23 patients had two operations for TR.
Results.
At the time of second surgery, almost half of the patients had experienced progression into high-grade gliomas (HGGs).
Univariate analysis showed that TR is influenced by the following: extent of resection (EOR) ( P < 0.002 ), ΔVT2T1 value ( P < 0.001 ), histological diagnosis of oligodendroglioma ( P = 0.017 ), and mutation of IDH1 ( P = 0.022 ).
The multivariate analysis showed that EOR at first surgery was the independent predictor for TR ( P < 0.001 ).
Conclusions.
In patients with insular LGG the EOR at first surgery represents the major predictive factor for TR.
At time of TR, more than 50% of cases had progressed in HGG, raising the question of the oncological management after the first surgery.
American Psychological Association (APA)
Ius, Tamara& Pauletto, Giada& Cesselli, Daniela& Isola, Miriam& Turella, Luca& Budai, Riccardo…[et al.]. 2015. Second Surgery in Insular Low-Grade Gliomas. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055705
Modern Language Association (MLA)
Ius, Tamara…[et al.]. Second Surgery in Insular Low-Grade Gliomas. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1055705
American Medical Association (AMA)
Ius, Tamara& Pauletto, Giada& Cesselli, Daniela& Isola, Miriam& Turella, Luca& Budai, Riccardo…[et al.]. Second Surgery in Insular Low-Grade Gliomas. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055705
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055705