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Identification of Subtype Specific miRNA-mRNA Functional Regulatory Modules in Matched miRNA-mRNA Expression Data: Multiple Myeloma as a Case
Joint Authors
Xu, Yanjun
Yang, Haixiu
Li, Yixue
Li, Chunquan
Wang, Yingying
Zhang, Chunlong
Li, Xia
Su, Fei
Liu, Wei
Zhang, Yunpeng
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-19
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Identification of miRNA-mRNA modules is an important step to elucidate their combinatorial effect on the pathogenesis and mechanisms underlying complex diseases.
Current identification methods primarily are based upon miRNA-target information and matched miRNA and mRNA expression profiles.
However, for heterogeneous diseases, the miRNA-mRNA regulatory mechanisms may differ between subtypes, leading to differences in clinical behavior.
In order to explore the pathogenesis of each subtype, it is important to identify subtype specific miRNA-mRNA modules.
In this study, we integrated the Ping-Pong algorithm and multiobjective genetic algorithm to identify subtype specific miRNA-mRNA functional regulatory modules (MFRMs) through integrative analysis of three biological data sets: GO biological processes, miRNA target information, and matched miRNA and mRNA expression data.
We applied our method on a heterogeneous disease, multiple myeloma (MM), to identify MM subtype specific MFRMs.
The constructed miRNA-mRNA regulatory networks provide modular outlook at subtype specific miRNA-mRNA interactions.
Furthermore, clustering analysis demonstrated that heterogeneous MFRMs were able to separate corresponding MM subtypes.
These subtype specific MFRMs may aid in the further elucidation of the pathogenesis of each subtype and may serve to guide MM subtype diagnosis and treatment.
American Psychological Association (APA)
Zhang, Yunpeng& Liu, Wei& Xu, Yanjun& Li, Chunquan& Wang, Yingying& Yang, Haixiu…[et al.]. 2015. Identification of Subtype Specific miRNA-mRNA Functional Regulatory Modules in Matched miRNA-mRNA Expression Data: Multiple Myeloma as a Case. BioMed Research International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1055709
Modern Language Association (MLA)
Zhang, Yunpeng…[et al.]. Identification of Subtype Specific miRNA-mRNA Functional Regulatory Modules in Matched miRNA-mRNA Expression Data: Multiple Myeloma as a Case. BioMed Research International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1055709
American Medical Association (AMA)
Zhang, Yunpeng& Liu, Wei& Xu, Yanjun& Li, Chunquan& Wang, Yingying& Yang, Haixiu…[et al.]. Identification of Subtype Specific miRNA-mRNA Functional Regulatory Modules in Matched miRNA-mRNA Expression Data: Multiple Myeloma as a Case. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1055709
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055709