Cardamonin Regulates miR-21 Expression and Suppresses Angiogenesis Induced by Vascular Endothelial Growth Factor
Joint Authors
Lu, Jin-Jian
Jiang, Fu-Sheng
Tian, Sha-Sha
Ding, Xing-Hong
Qian, Chao-Dong
Ding, Bin
Ding, Zhi-Shan
Jin, Bo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cardamonin has promising potential in cancer prevention and therapy by interacting with proteins and modifying the expressions and activities, including factors of cell survival, proliferation, and angiogenesis.
In our precious study, we have demonstrated that cardamonin suppressed vascular endothelial growth factor- (VEGF-) induced angiogenesis as evaluated in the mouse aortic ring assay.
It is also known that microRNAs (miRNAs) play important roles in angiogenesis.
Herein, we hypothesized whether antiangiogenesis effect of cardamonin in human umbilical vein endothelial cells (HUVECs) triggered by VEGF was associated with miRNAs.
We found that cardamonin reduced the miR-21 expression induced by VEGF in HUVECs.
Treatment with miR-21 mimics abolished the effects of cardamonin on VEGF-induced cell proliferation, migration, and angiogenesis in HUVECs.
However, treatment with miR-21 inhibitors presented the opposite effects, indicating the vital role of miR-21 in this process.
Our study provides a new insight of the preliminary mechanism of anti-VEGF-induced angiogenesis by cardamonin in HUVECs.
American Psychological Association (APA)
Jiang, Fu-Sheng& Tian, Sha-Sha& Lu, Jin-Jian& Ding, Xing-Hong& Qian, Chao-Dong& Ding, Bin…[et al.]. 2015. Cardamonin Regulates miR-21 Expression and Suppresses Angiogenesis Induced by Vascular Endothelial Growth Factor. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055712
Modern Language Association (MLA)
Jiang, Fu-Sheng…[et al.]. Cardamonin Regulates miR-21 Expression and Suppresses Angiogenesis Induced by Vascular Endothelial Growth Factor. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055712
American Medical Association (AMA)
Jiang, Fu-Sheng& Tian, Sha-Sha& Lu, Jin-Jian& Ding, Xing-Hong& Qian, Chao-Dong& Ding, Bin…[et al.]. Cardamonin Regulates miR-21 Expression and Suppresses Angiogenesis Induced by Vascular Endothelial Growth Factor. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055712
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055712