Endogenous Generation and Signaling Actions of Omega-3 Fatty Acid Electrophilic Derivatives
Author
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-03
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Dietary omega-3 polyunsaturated fatty acids (PUFAs) are beneficial for a number of conditions ranging from cardiovascular disease to chronic airways disorders, neurodegeneration, and cancer.
Growing evidence has shown that bioactive oxygenated derivatives are responsible for transducing these salutary effects.
Electrophilic oxo-derivatives of omega-3 PUFAs represent a class of oxidized derivatives that can be generated via enzymatic and nonenzymatic pathways.
Inflammation and oxidative stress favor the formation of these signaling species to promote the resolution of inflammation within a fine autoregulatory loop.
Endogenous generation of electrophilic oxo-derivatives of omega-3 PUFAs has been observed in in vitro and ex vivo human models and dietary supplementation of omega-3 PUFAs has been reported to increase their formation.
Due to the presence of an α,β-unsaturated ketone moiety, these compounds covalently and reversibly react with nucleophilic residues on target proteins triggering the activation of cytoprotective pathways, including the Nrf2 antioxidant response, the heat shock response, and the peroxisome proliferator activated receptor γ (PPARγ) and suppressing the NF-κB proinflammatory pathway.
The endogenous nature of electrophilic oxo-derivatives of omega-3 PUFAs combined with their ability to simultaneously activate multiple cytoprotective pathways has made these compounds attractive for the development of new therapies for the treatment of chronic disorders and acute events characterized by inflammation and oxidative stress.
American Psychological Association (APA)
Cipollina, Chiara. 2015. Endogenous Generation and Signaling Actions of Omega-3 Fatty Acid Electrophilic Derivatives. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055713
Modern Language Association (MLA)
Cipollina, Chiara. Endogenous Generation and Signaling Actions of Omega-3 Fatty Acid Electrophilic Derivatives. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1055713
American Medical Association (AMA)
Cipollina, Chiara. Endogenous Generation and Signaling Actions of Omega-3 Fatty Acid Electrophilic Derivatives. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055713
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055713