Preventive Effect of Liothyronine on Electroconvulsive Therapy-Induced Memory Deficit in Patients with Major Depressive Disorder: A Double-Blind Controlled Clinical Trial
Joint Authors
Amiri, Shahrokh
Mohagheghi, Arash
Arfaie, Asghar
Nouri, Masoud
Safikhanlou, Salman
Abdi, Salman
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-06
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction and Objective.
Despite the effectiveness of electroconvulsive therapy (ECT) in treating major depressive disorder (MDD), its cognitive side effects make it less popular.
This study investigated the impact of liothyronine on ECT-induced memory deficit in patients with MDD.
Methodology.
This is a double-blind clinical trial, in which 60 patients with MDD who were referred for ECT were selected.
The diagnosis was based on the criteria of DSM-IV-TR.
Patients were divided randomly into two groups to receive either liothyronine (50 mcg every morning) or placebo.
After the assessment with Wechsler Memory Scale-Revised (WMS-R) before first session of ECT, posttests were repeated again, two months after the completion of ECT.
Findings.
By controlling the pretest scores, the mean scores of the experimental group were higher than the control group in delayed recall, verbal memory, visual memory, general memory, and attention/concentration scales (P<0.05).
Conclusion.
Liothyronine may prevent ECT-induced memory impairment in patients with MDD.
This study has been registered in IRCT under IRCT201401122660N2.
American Psychological Association (APA)
Mohagheghi, Arash& Arfaie, Asghar& Amiri, Shahrokh& Nouri, Masoud& Abdi, Salman& Safikhanlou, Salman. 2015. Preventive Effect of Liothyronine on Electroconvulsive Therapy-Induced Memory Deficit in Patients with Major Depressive Disorder: A Double-Blind Controlled Clinical Trial. BioMed Research International،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1055720
Modern Language Association (MLA)
Mohagheghi, Arash…[et al.]. Preventive Effect of Liothyronine on Electroconvulsive Therapy-Induced Memory Deficit in Patients with Major Depressive Disorder: A Double-Blind Controlled Clinical Trial. BioMed Research International No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1055720
American Medical Association (AMA)
Mohagheghi, Arash& Arfaie, Asghar& Amiri, Shahrokh& Nouri, Masoud& Abdi, Salman& Safikhanlou, Salman. Preventive Effect of Liothyronine on Electroconvulsive Therapy-Induced Memory Deficit in Patients with Major Depressive Disorder: A Double-Blind Controlled Clinical Trial. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1055720
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055720