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Disorders of MicroRNAs in Peripheral Blood Mononuclear Cells: As Novel Biomarkers of Ankylosing Spondylitis and Provocative Therapeutic Targets
Joint Authors
Li, Qiuxia
Huang, Jianlin
Lv, Qing
Zhang, Peizhuo
Jiang, Yingjuan
Wang, Xinwei
Wei, Qiujing
Cao, Shuangyan
Liao, Zetao
Lin, Zhiming
Pan, Yunfeng
Li, Tianwang
Jin, Ou
Wu, Yuqiong
Gu, Jieruo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
MicroRNAs can potentially regulate every aspect of cellular activity.
In this study, we investigated whether AS pathogenesis involves microRNAs disorders.
Result.
The expression of 2 microRNAs, hsa-miR-126-3p and hsa-miR-29a, was significantly lower in active AS group before etanercept therapy than in control group.
Marched fold changes of them were 3.76 and 16.22.
Moreover, expressions of hsa-miR-126-3p and hsa-miR-29a were dramatically upregulated after 12-weeks etanercept treatment.
Fold changes were 2.20 and 3.18.
All regulations of microRNAs expression mentioned before were statistically significant (fold change >2 and P<0.05).
The expression disorders of the 2 microRNAs did not statistically significantly correlated with BASDAI, CRP, and ESR.
Conclusion.
AS pathogenesis involved dysregulation of microRNAs.
Hsa-miR-126-3p and hsa-miR-29a will probably become the potential biomarkers and provocative therapeutic targets of AS.
American Psychological Association (APA)
Lv, Qing& Li, Qiuxia& Zhang, Peizhuo& Jiang, Yingjuan& Wang, Xinwei& Wei, Qiujing…[et al.]. 2015. Disorders of MicroRNAs in Peripheral Blood Mononuclear Cells: As Novel Biomarkers of Ankylosing Spondylitis and Provocative Therapeutic Targets. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055722
Modern Language Association (MLA)
Lv, Qing…[et al.]. Disorders of MicroRNAs in Peripheral Blood Mononuclear Cells: As Novel Biomarkers of Ankylosing Spondylitis and Provocative Therapeutic Targets. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1055722
American Medical Association (AMA)
Lv, Qing& Li, Qiuxia& Zhang, Peizhuo& Jiang, Yingjuan& Wang, Xinwei& Wei, Qiujing…[et al.]. Disorders of MicroRNAs in Peripheral Blood Mononuclear Cells: As Novel Biomarkers of Ankylosing Spondylitis and Provocative Therapeutic Targets. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055722
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055722