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Anti-Lung Cancer Activity of the Curcumin Analog JZ534 In Vitro
Joint Authors
Wu, Jianzhang
Cai, Zhijian
Wei, Xiaoyan
Chen, Minxiao
Ying, Shilong
Shi, Lingyi
Xu, Ren-Ai
He, Fan
Liang, Guang
Zhang, Xiuhua
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This study investigated the anticancer effect of the curcumin analog JZ534 on lung cancer cell lines H460, A549, H1975, and HCC827.
The antiproliferation effect of JZ534 was measured through the methylthiazoletetrazolium assay, and cell colony formation was observed.
Cell cycle and apoptosis were determined by flow cytometry, and the preliminary mechanism was studied by Western blot.
Results showed that JZ534 significantly inhibited the vitality and colony formation of lung cancer cells.
JZ534 induced the G2/M cell cycle arrest of the cancer cells and suppressed the expression of cycle-related proteins, including cyclin B1 and Cdc2.
Meanwhile, JZ534 induced cell apoptosis and upregulated the expression of apoptosis-related proteins, including cleaved caspase-3, Bax, and p53.
At the same dose, JZ534 showed better antitumor activity than curcumin.
These results suggest that JZ534 exhibits excellent anti-lung cancer activity by inhibiting the growth and inducing the apoptosis of lung cancer cells.
Therefore, JZ534 is a promising lead compound for cancer treatment.
American Psychological Association (APA)
Wu, Jianzhang& Cai, Zhijian& Wei, Xiaoyan& Chen, Minxiao& Ying, Shilong& Shi, Lingyi…[et al.]. 2015. Anti-Lung Cancer Activity of the Curcumin Analog JZ534 In Vitro. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055724
Modern Language Association (MLA)
Wu, Jianzhang…[et al.]. Anti-Lung Cancer Activity of the Curcumin Analog JZ534 In Vitro. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1055724
American Medical Association (AMA)
Wu, Jianzhang& Cai, Zhijian& Wei, Xiaoyan& Chen, Minxiao& Ying, Shilong& Shi, Lingyi…[et al.]. Anti-Lung Cancer Activity of the Curcumin Analog JZ534 In Vitro. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055724
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055724