The Relationship of CSF and Plasma Cytokine Levels in HIV Infected Patients with Neurocognitive Impairment
Joint Authors
Yuan, Lin
Liu, An
Qiao, Luxin
Sheng, Bo
Xu, Meng
Li, Wei
Chen, Dexi
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Although HAD is now rare due to HAART, the milder forms of HAND persist in HIV-infected patients.
HIV-induced systemic and localized inflammation is considered to be one of the mechanisms of HAND.
The levels of cytokines in CSF were associated with neurocognitive impairment in HIV infection.
However, the changes of cytokines involved in cognition impairment in plasma have not been shown, and their relationships between CSF and plasma require to be addressed.
We compared cytokine levels in paired CSF and plasma samples from HIV-infected individuals with or without neurocognitive impairment.
Cytokine concentrations were measured by Luminex xMAP.
In comparing the expression levels of cytokines in plasma and CSF, IFN-α2, IL-8, IP-10, and MCP-1 were significantly higher in CSF.
Eotaxin was significantly higher in plasma, whereas G-CSF showed no difference between plasma and CSF.
G-CSF (P=0.0079), IL-8 (P=0.0223), IP-10 (P=0.0109), and MCP-1 (P=0.0497) in CSF showed significant difference between HIV-CI and HIV-NC group, which may indicate their relationship to HIV associated neurocognitive impairment.
In addition, G-CSF (P=0.0191) and IP-10 (P=0.0377) in plasma were significantly higher in HIV-CI than HIV-NC.
The consistent changes of G-CSF and IP-10 in paired plasma and CSF samples might enhance their potential for predicting HAND.
American Psychological Association (APA)
Yuan, Lin& Liu, An& Qiao, Luxin& Sheng, Bo& Xu, Meng& Li, Wei…[et al.]. 2015. The Relationship of CSF and Plasma Cytokine Levels in HIV Infected Patients with Neurocognitive Impairment. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055743
Modern Language Association (MLA)
Yuan, Lin…[et al.]. The Relationship of CSF and Plasma Cytokine Levels in HIV Infected Patients with Neurocognitive Impairment. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1055743
American Medical Association (AMA)
Yuan, Lin& Liu, An& Qiao, Luxin& Sheng, Bo& Xu, Meng& Li, Wei…[et al.]. The Relationship of CSF and Plasma Cytokine Levels in HIV Infected Patients with Neurocognitive Impairment. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055743
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055743