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S100B Inhibitor Pentamidine Attenuates Reactive Gliosis and Reduces Neuronal Loss in a Mouse Model of Alzheimer’s Disease
Joint Authors
Sarnelli, Giovanni
Cirillo, Carla
Capoccia, Elena
Iuvone, Teresa
Cuomo, Rosario
Steardo, Luca
Esposito, Giuseppe
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Among the different signaling molecules released during reactive gliosis occurring in Alzheimer’s disease (AD), the astrocyte-derived S100B protein plays a key role in neuroinflammation, one of the hallmarks of the disease.
The use of pharmacological tools targeting S100B may be crucial to embank its effects and some of the pathological features of AD.
The antiprotozoal drug pentamidine is a good candidate since it directly blocks S100B activity by inhibiting its interaction with the tumor suppressor p53.
We used a mouse model of amyloid beta- (Aβ-) induced AD, which is characterized by reactive gliosis and neuroinflammation in the brain, and we evaluated the effect of pentamidine on the main S100B-mediated events.
Pentamidine caused the reduction of glial fibrillary acidic protein, S100B, and RAGE protein expression, which are signs of reactive gliosis, and induced p53 expression in astrocytes.
Pentamidine also reduced the expression of proinflammatory mediators and markers, thus reducing neuroinflammation in AD brain.
In parallel, we observed a significant neuroprotection exerted by pentamidine on CA1 pyramidal neurons.
We demonstrated that pentamidine inhibits Aβ-induced gliosis and neuroinflammation in an animal model of AD, thus playing a role in slowing down the course of the disease.
American Psychological Association (APA)
Cirillo, Carla& Capoccia, Elena& Iuvone, Teresa& Cuomo, Rosario& Sarnelli, Giovanni& Steardo, Luca…[et al.]. 2015. S100B Inhibitor Pentamidine Attenuates Reactive Gliosis and Reduces Neuronal Loss in a Mouse Model of Alzheimer’s Disease. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055751
Modern Language Association (MLA)
Cirillo, Carla…[et al.]. S100B Inhibitor Pentamidine Attenuates Reactive Gliosis and Reduces Neuronal Loss in a Mouse Model of Alzheimer’s Disease. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1055751
American Medical Association (AMA)
Cirillo, Carla& Capoccia, Elena& Iuvone, Teresa& Cuomo, Rosario& Sarnelli, Giovanni& Steardo, Luca…[et al.]. S100B Inhibitor Pentamidine Attenuates Reactive Gliosis and Reduces Neuronal Loss in a Mouse Model of Alzheimer’s Disease. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055751
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055751