Variations in Antioxidant Genes and Male Infertility
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Oxidative stress and reactive oxygen species (ROS) are generated from both endogenous and environmental resources, which in turn may cause defective spermatogenesis and male infertility.
Antioxidant genes, which include catalase (CAT), glutathione peroxidase (GPX), glutathione S-transferase (GST), nitric oxide synthase (NOS), nuclear factor erythroid 2-related factor 2 (NRF2), and superoxide dismutase (SOD), play important roles in spermatogenesis and normal sperm function.
In this review, we discuss the association between variations in major antioxidant genes and male infertility.
Numerous studies have suggested that genetic disruption or functional polymorphisms in these antioxidant genes are associated with a higher risk for male infertility, which include low sperm quality, oligoasthenoteratozoospermia, oligozoospermia, and subfertility.
The synergistic effects of environmental ROS and functional polymorphisms on antioxidant genes that result in male infertility have also been reported.
Therefore, variants in antioxidant genes, which independently or synergistically occur with environmental ROS, affect spermatogenesis and contribute to the occurrence of male infertility.
Large cohort and multiple center-based population studies to identify new antioxidant genetic variants that increase susceptibility to male infertility as well as validate its potential as genetic markers for diagnosis and risk assessment for male infertility for precise clinical approaches are warranted.
American Psychological Association (APA)
Yu, Bolan& Huang, Zhaofeng. 2015. Variations in Antioxidant Genes and Male Infertility. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055767
Modern Language Association (MLA)
Yu, Bolan& Huang, Zhaofeng. Variations in Antioxidant Genes and Male Infertility. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1055767
American Medical Association (AMA)
Yu, Bolan& Huang, Zhaofeng. Variations in Antioxidant Genes and Male Infertility. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055767
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055767