Prognosis Relevance of Serum Cytokines in Pancreatic Cancer
Joint Authors
Perales, Sonia
Palomino-Morales, Rogelio
Rojas, I.
Prados, J.
Aránega, A.
Torres, Carolina
Alejandre, Maria José
Caba, Octavio
Delgado, Juan R.
Irigoyen, Antonio
Martínez-Galán, Joaquina
Ortuño, Francisco M.
Linares, Ana
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-04
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The overall survival of patients with pancreatic ductal adenocarcinoma is extremely low.
Although gemcitabine is the standard used chemotherapy for this disease, clinical outcomes do not reflect significant improvements, not even when combined with adjuvant treatments.
There is an urgent need for prognosis markers to be found.
The aim of this study was to analyze the potential value of serum cytokines to find a profile that can predict the clinical outcome in patients with pancreatic cancer and to establish a practical prognosis index that significantly predicts patients’ outcomes.
We have conducted an extensive analysis of serum prognosis biomarkers using an antibody array comprising 507 human cytokines.
Overall survival was estimated using the Kaplan-Meier method.
Univariate and multivariate Cox’s proportional hazard models were used to analyze prognosis factors.
To determine the extent that survival could be predicted based on this index, we used the leave-one-out cross-validation model.
The multivariate model showed a better performance and it could represent a novel panel of serum cytokines that correlates to poor prognosis in pancreatic cancer.
B7-1/CD80, EG-VEGF/PK1, IL-29, NRG1-beta1/HRG1-beta1, and PD-ECGF expressions portend a poor prognosis for patients with pancreatic cancer and these cytokines could represent novel therapeutic targets for this disease.
American Psychological Association (APA)
Torres, Carolina& Linares, Ana& Alejandre, Maria José& Palomino-Morales, Rogelio& Caba, Octavio& Prados, J.…[et al.]. 2015. Prognosis Relevance of Serum Cytokines in Pancreatic Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055795
Modern Language Association (MLA)
Torres, Carolina…[et al.]. Prognosis Relevance of Serum Cytokines in Pancreatic Cancer. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1055795
American Medical Association (AMA)
Torres, Carolina& Linares, Ana& Alejandre, Maria José& Palomino-Morales, Rogelio& Caba, Octavio& Prados, J.…[et al.]. Prognosis Relevance of Serum Cytokines in Pancreatic Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055795
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055795