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NamptPBEFVisfatin Upregulation in Colorectal Tumors, Mirrored in Normal Tissue and Whole Blood of Colorectal Cancer Patients, Is Associated with Metastasis, Hypoxia, IL1β, and Anemia
Joint Authors
Gamian, Andrzej
Bednarz Misa, Iwona
Kapturkiewicz, Bartosz
Krzystek-Korpacka, Malgorzata
Neubauer, Katarzyna
Diakowska, Dorota
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Targeting Nampt/PBEF/visfatin is considered a promising anticancer strategy, yet little is known about its association with colorectal cancer (CRC).
We quantified Nampt/PBEF/visfatin expression in bowel and blood (mRNA and protein), referring it to CRC advancement and inflammatory, angiogenic, hypoxia, and proliferation indices.
Tumor Nampt/PBEF/visfatin upregulation was associated with metastasis, anemia, tumor location, HIF1α, and inflammatory and angiogenic indices, of which HIF1α, IL1β, and anemia explained 70% in Nampt/PBEF/visfatin variability.
Nampt/PBEF/visfatin expression in nontumor tissue, both mRNA and protein, increased in patients with metastatic disease and mild anemia, and, on transcriptional level, correlated with HIF1α, IL1β, IL8, CCL2, and CCL4 expression.
Whole blood Nampt/PBEF/visfatin tended to be elevated in patients with metastatic cancer or anemia and correlated with inflammatory indices, of which IL1β, IL8, and hematocrit explained 60% of its variability.
Circulating visfatin was associated with lymph node metastasis and inflammatory and angiogenic indices.
In vitro experiments on SW620 cells demonstrated Nampt/PBEF/visfatin downregulation in response to serum withdrawal but its upregulation in response to serum induction and hypoxia.
Stimulation with recombinant visfatin did not provide growth advantage.
Summarizing, our results link Nampt/PBEF/visfatin with tumor metastatic potential and point at inflammation and hypoxia as key inducers of its upregulation in CRC.
American Psychological Association (APA)
Neubauer, Katarzyna& Bednarz Misa, Iwona& Diakowska, Dorota& Kapturkiewicz, Bartosz& Gamian, Andrzej& Krzystek-Korpacka, Malgorzata. 2015. NamptPBEFVisfatin Upregulation in Colorectal Tumors, Mirrored in Normal Tissue and Whole Blood of Colorectal Cancer Patients, Is Associated with Metastasis, Hypoxia, IL1β, and Anemia. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055813
Modern Language Association (MLA)
Neubauer, Katarzyna…[et al.]. NamptPBEFVisfatin Upregulation in Colorectal Tumors, Mirrored in Normal Tissue and Whole Blood of Colorectal Cancer Patients, Is Associated with Metastasis, Hypoxia, IL1β, and Anemia. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1055813
American Medical Association (AMA)
Neubauer, Katarzyna& Bednarz Misa, Iwona& Diakowska, Dorota& Kapturkiewicz, Bartosz& Gamian, Andrzej& Krzystek-Korpacka, Malgorzata. NamptPBEFVisfatin Upregulation in Colorectal Tumors, Mirrored in Normal Tissue and Whole Blood of Colorectal Cancer Patients, Is Associated with Metastasis, Hypoxia, IL1β, and Anemia. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055813
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055813