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Salvianolic Acids Attenuate Rat Hippocampal Injury after Acute CO Poisoning by Improving Blood Flow Properties
Joint Authors
Guan, Li
Zhang, Yan-Lin
Li, Zong-Yang
Zhu, Ming-Xia
Yao, Wei-Juan
Zhao, Jin-Yuan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Carbon monoxide (CO) poisoning causes the major injury and death due to poisoning worldwide.
The most severe damage via CO poisoning is brain injury and mortality.
Delayed encephalopathy after acute CO poisoning (DEACMP) occurs in forty percent of the survivors of acute CO exposure.
But the pathological cause for DEACMP is not well understood.
And the corresponding therapy is not well developed.
In order to investigate the effects of salvianolic acid (SA) on brain injury caused by CO exposure from the view point of hemorheology, we employed a rat model and studied the dynamic of blood changes in the hemorheological and coagulative properties over acute CO exposure.
Compared with the groups of CO and 20% mannitol + CO treatments, the severe hippocampal injury caused by acute CO exposure was prevented by SA treatment.
These protective effects were associated with the retaining level of hematocrit (Hct), plasma viscosity, fibrinogen, whole blood viscosities and malondialdehyde (MDA) levels in red blood cells (RBCs).
These results indicated that SA treatment could significantly improve the deformation of erythrocytes and prevent the damage caused by CO poisoning.
Meanwhile, hemorheological indexes are good indicators for monitoring the pathological dynamic after acute CO poisoning.
American Psychological Association (APA)
Guan, Li& Zhang, Yan-Lin& Li, Zong-Yang& Zhu, Ming-Xia& Yao, Wei-Juan& Zhao, Jin-Yuan. 2015. Salvianolic Acids Attenuate Rat Hippocampal Injury after Acute CO Poisoning by Improving Blood Flow Properties. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055823
Modern Language Association (MLA)
Guan, Li…[et al.]. Salvianolic Acids Attenuate Rat Hippocampal Injury after Acute CO Poisoning by Improving Blood Flow Properties. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055823
American Medical Association (AMA)
Guan, Li& Zhang, Yan-Lin& Li, Zong-Yang& Zhu, Ming-Xia& Yao, Wei-Juan& Zhao, Jin-Yuan. Salvianolic Acids Attenuate Rat Hippocampal Injury after Acute CO Poisoning by Improving Blood Flow Properties. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055823
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055823