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Functional Roles of Calreticulin in Cancer Biology
Joint Authors
Lu, Yi-Chien
Weng, Wen-Chin
Lee, Hsinyu
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Calreticulin is a highly conserved endoplasmic reticulum chaperone protein which participates in various cellular processes.
It was first identified as a Ca2+-binding protein in 1974.
Accumulated evidences indicate that calreticulin has great impacts for the development of different cancers and the effect of calreticulin on tumor formation and progression may depend on cell types and clinical stages.
Cell surface calreticulin is considered as an “eat-me” signal and promotes phagocytic uptake of cancer cells by immune system.
Moreover, several reports reveal that manipulation of calreticulin levels profoundly affects cancer cell proliferation and angiogenesis as well as differentiation.
In addition to immunogenicity and tumorigenesis, interactions between calreticulin and integrins have been described during cell adhesion, which is an essential process for cancer metastasis.
Integrins are heterodimeric transmembrane receptors which connect extracellular matrix and intracellular cytoskeleton and trigger inside-out or outside-in signaling transduction.
More and more evidences reveal that proteins binding to integrins might affect integrin-cytoskeleton interaction and therefore influence ability of cell adhesion.
Here, we reviewed the biological roles of calreticulin and summarized the potential mechanisms of calreticulin in regulating mRNA stability and therefore contributed to cancer metastasis.
American Psychological Association (APA)
Lu, Yi-Chien& Weng, Wen-Chin& Lee, Hsinyu. 2015. Functional Roles of Calreticulin in Cancer Biology. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055824
Modern Language Association (MLA)
Lu, Yi-Chien…[et al.]. Functional Roles of Calreticulin in Cancer Biology. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055824
American Medical Association (AMA)
Lu, Yi-Chien& Weng, Wen-Chin& Lee, Hsinyu. Functional Roles of Calreticulin in Cancer Biology. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055824
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055824