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Effect of Fe3O4 Nanoparticles on Skin Tumor Cells and Dermal Fibroblasts
Joint Authors
Alili, Lirija
Chapiro, Swetlana
Marten, Gernot U.
Schmidt, Annette M.
Zanger, Klaus
Brenneisen, Peter
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Iron oxide (Fe3O4) nanoparticles have been used in many biomedical approaches.
The toxicity of Fe3O4 nanoparticles on mammalian cells was published recently.
Though, little is known about the viability of human cells after treatment with Fe3O4 nanoparticles.
Herein, we examined the toxicity, production of reactive oxygen species, and invasive capacity after treatment of human dermal fibroblasts (HDF) and cells of the squamous tumor cell line (SCL-1) with Fe3O4 nanoparticles.
These nanoparticles had an average size of 65 nm.
Fe3O4 nanoparticles induced oxidative stress via generation of reactive oxygen species (ROS) and subsequent initiation of lipid peroxidation.
Furthermore, the question was addressed of whether Fe3O4 nanoparticles affect myofibroblast formation, known to be involved in tumor invasion.
Herein, Fe3O4 nanoparticles prevent the expression alpha-smooth muscle actin and therefore decrease the number of myofibroblastic cells.
Moreover, our data show in vitro that concentrations of Fe3O4 nanoparticles, which are nontoxic for normal cells, partially reveal a ROS-triggered cytotoxic but also a pro-invasive effect on the fraction of squamous cancer cells surviving the treatment with Fe3O4 nanoparticles.
The data herein show that the Fe3O4 nanoparticles appear not to be adequate for use in therapeutic approaches against cancer cells, in contrast to recently published data with cerium oxide nanoparticles.
American Psychological Association (APA)
Alili, Lirija& Chapiro, Swetlana& Marten, Gernot U.& Schmidt, Annette M.& Zanger, Klaus& Brenneisen, Peter. 2015. Effect of Fe3O4 Nanoparticles on Skin Tumor Cells and Dermal Fibroblasts. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055843
Modern Language Association (MLA)
Alili, Lirija…[et al.]. Effect of Fe3O4 Nanoparticles on Skin Tumor Cells and Dermal Fibroblasts. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1055843
American Medical Association (AMA)
Alili, Lirija& Chapiro, Swetlana& Marten, Gernot U.& Schmidt, Annette M.& Zanger, Klaus& Brenneisen, Peter. Effect of Fe3O4 Nanoparticles on Skin Tumor Cells and Dermal Fibroblasts. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055843
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055843