Epigenetics of Meningiomas
Joint Authors
Murnyák, Balázs
Bognár, László
Klekner, Álmos
Hortobágyi, Tibor
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Meningiomas account for one-third of all adult central nervous system tumours and are divided into three WHO grades.
In contrast to the relatively well characterized genetic alterations, our current understanding of epigenetic modifications involved in the meningioma-genesis and progression is rather incomplete.
Contrary to genetic alterations, epigenetic changes do not alter the primary DNA sequence and their reversible nature serves as an excellent basis for prevention and development of novel personalised tumour therapies.
Indeed, growing body of evidence suggests that disturbed epigenetic regulation plays a key role in the pathogenesis of meningiomas.
Altered DNA methylation, microRNA expression, histone, and chromatin modifications are frequently noted in meningiomas bearing prognostic and therapeutic relevance.
In this review we provide an overview on recently identified epigenetic alterations in meningiomas and discuss their role in tumour initiation, progression, and recurrence.
American Psychological Association (APA)
Murnyák, Balázs& Bognár, László& Klekner, Álmos& Hortobágyi, Tibor. 2015. Epigenetics of Meningiomas. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055848
Modern Language Association (MLA)
Murnyák, Balázs…[et al.]. Epigenetics of Meningiomas. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1055848
American Medical Association (AMA)
Murnyák, Balázs& Bognár, László& Klekner, Álmos& Hortobágyi, Tibor. Epigenetics of Meningiomas. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055848
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055848