Insulin-Like Growth Factor System in Cancer: Novel Targeted Therapies
Joint Authors
Brahmkhatri, Varsha P.
Prasanna, Chinmayi
Atreya, Hanudatta S.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-24, 24 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-19
Country of Publication
Egypt
No. of Pages
24
Main Subjects
Abstract EN
Insulin-like growth factors (IGFs) are essential for growth and survival that suppress apoptosis and promote cell cycle progression, angiogenesis, and metastatic activities in various cancers.
The IGFs actions are mediated through the IGF-1 receptor that is involved in cell transformation induced by tumour.
These effects depend on the bioavailability of IGFs, which is regulated by IGF binding proteins (IGFBPs).
We describe here the role of the IGF system in cancer, proposing new strategies targeting this system.
We have attempted to expand the general viewpoint on IGF-1R, its inhibitors, potential limitations of IGF-1R, antibodies and tyrosine kinase inhibitors, and IGFBP actions.
This review discusses the emerging view that blocking IGF via IGFBP is a better option than blocking IGF receptors.
This can lead to the development of novel cancer therapies.
American Psychological Association (APA)
Brahmkhatri, Varsha P.& Prasanna, Chinmayi& Atreya, Hanudatta S.. 2015. Insulin-Like Growth Factor System in Cancer: Novel Targeted Therapies. BioMed Research International،Vol. 2015, no. 2015, pp.1-24.
https://search.emarefa.net/detail/BIM-1055869
Modern Language Association (MLA)
Brahmkhatri, Varsha P.…[et al.]. Insulin-Like Growth Factor System in Cancer: Novel Targeted Therapies. BioMed Research International No. 2015 (2015), pp.1-24.
https://search.emarefa.net/detail/BIM-1055869
American Medical Association (AMA)
Brahmkhatri, Varsha P.& Prasanna, Chinmayi& Atreya, Hanudatta S.. Insulin-Like Growth Factor System in Cancer: Novel Targeted Therapies. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-24.
https://search.emarefa.net/detail/BIM-1055869
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055869