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The Impact of LEP G-2548A and LEPR Gln223Arg Polymorphisms on Adiposity, Leptin, and Leptin-Receptor Serum Levels in a MexicanMestizo Population
Joint Authors
Martín-Márquez, Beatriz Teresita
Gómez-Bañuelos, Eduardo
Navarro-Hernandez, Rosa Elena
Castro-Albarran, Jorge
Ruíz-Quezada, Sandra-Luz
Chavarria-Avila, Efraín
Sánchez-López, Lizeth
Vázquez-Del Mercado, Mónica
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The polymorphisms in leptin (LEP G-2548A) and leptin-receptor (LEPR Gln223Arg) seem to influence obesity and lipid metabolism among others.
The aim of this study was to investigate the effect of these polymorphisms on adiposity, leptin (sLeptin), and leptin-receptor (sLeptin-receptor) serum concentrations as well as inflammation markers.
We included 382 adults originally from Western Mexico.
They were genotyped by PCR-RFLP.
Obese individuals showed higher sLeptin ( 58.2 ± 31.35 ng/mL) but lower sLeptin-receptor ( 12.6 ± 3.74 ng/mL) levels than normal weight ones ( 17.6 ± 14.62 ng/mL, 17.4 ± 4.62 ng/mL, resp.), P < 0.001 .
Obese subjects carriers of Arg/Arg genotype had more ( P = 0.016 ) sLeptin-receptor ( 14.7 ± 4.96 ng/mL) and less ( P = 0.004 ) sLeptin ( 44.0 ± 28.12 ng/mL) levels than Gln/Gln genotype ( 11.0 ± 2.92 ng/mL, 80.3 ± 33.24 ng/mL, resp.).
Body fat mass was lower (P from 0.003 to 0.045) for A/A ( 36.5 % ± 6.80 ) or Arg/Arg ( 36.8 % ± 6.82 ) genotypes with respect to G/G ( 41.3 % ± 5.52 ) and G/A ( 41.6 % ± 5.61 ) or Gln/Gln ( 43.7 % ± 4.74 ) and Gln/Arg ( 41.0 % ± 5.52 ) genotypes carriers.
Our results suggest that LEP -2548A and LEPR 223Arg could be genetic markers of less body fat mass accumulation in obese subjects from Western Mexico.
American Psychological Association (APA)
Chavarria-Avila, Efraín& Vázquez-Del Mercado, Mónica& Gómez-Bañuelos, Eduardo& Ruíz-Quezada, Sandra-Luz& Castro-Albarran, Jorge& Sánchez-López, Lizeth…[et al.]. 2015. The Impact of LEP G-2548A and LEPR Gln223Arg Polymorphisms on Adiposity, Leptin, and Leptin-Receptor Serum Levels in a MexicanMestizo Population. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055875
Modern Language Association (MLA)
Chavarria-Avila, Efraín…[et al.]. The Impact of LEP G-2548A and LEPR Gln223Arg Polymorphisms on Adiposity, Leptin, and Leptin-Receptor Serum Levels in a MexicanMestizo Population. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1055875
American Medical Association (AMA)
Chavarria-Avila, Efraín& Vázquez-Del Mercado, Mónica& Gómez-Bañuelos, Eduardo& Ruíz-Quezada, Sandra-Luz& Castro-Albarran, Jorge& Sánchez-López, Lizeth…[et al.]. The Impact of LEP G-2548A and LEPR Gln223Arg Polymorphisms on Adiposity, Leptin, and Leptin-Receptor Serum Levels in a MexicanMestizo Population. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055875