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Neonatal Death and Heart Failure in Mouse with Transgenic HSP60 Expression
Joint Authors
Chen, Tsung-Hsien
Liu, Shan-Wen
Chen, Mei-Ru
Cho, Kuan-Hung
Chen, Tzu-Yin
Kao, Yu-Ying
Hsu, Ching-Han
Lin, Kurt Ming-Chao
Chu, Pao-Hsien
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Mitochondrial heat shock proteins, such as HSP60, are chaperones responsible for the folding, transport, and quality control of mitochondrial matrix proteins and are essential for maintaining life.
Both prosurvival and proapoptotic roles have been proposed for HSP60, and HSP60 is reportedly involved in the initiation of autoimmune, metabolic, and cardiovascular diseases.
The role of HSP60 in pathogenesis of these diseases remains unclear, partly because of the lack of mouse models expressing HSP60.
In this study we generated HSP60 conditional transgenic mice suitable for investigating in vivo outcomes by expressing HSP60 at the targeted organ in disease models.
Ubiquitous HSP60 induction in the embryonic stage caused neonatal death in mice at postnatal day 1.
A high incidence of atrial septal defects was observed in HSP60-expressing mice, with increased apoptosis and myocyte degeneration that possibly contributed to massive hemorrhage and sponge-like cardiac muscles.
Our results showed that neonatal heart failure through HSP60 induction likely involves developmental defects and excessive apoptosis.
The conditional HSP60 mouse model is useful for studying crucial biological questions concerning HSP60.
American Psychological Association (APA)
Chen, Tsung-Hsien& Liu, Shan-Wen& Chen, Mei-Ru& Cho, Kuan-Hung& Chen, Tzu-Yin& Chu, Pao-Hsien…[et al.]. 2015. Neonatal Death and Heart Failure in Mouse with Transgenic HSP60 Expression. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055876
Modern Language Association (MLA)
Chen, Tsung-Hsien…[et al.]. Neonatal Death and Heart Failure in Mouse with Transgenic HSP60 Expression. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1055876
American Medical Association (AMA)
Chen, Tsung-Hsien& Liu, Shan-Wen& Chen, Mei-Ru& Cho, Kuan-Hung& Chen, Tzu-Yin& Chu, Pao-Hsien…[et al.]. Neonatal Death and Heart Failure in Mouse with Transgenic HSP60 Expression. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055876
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055876