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The Correlation between miRNA and Lymph Node Metastasis in Gastric Cancer
Joint Authors
Lo, Su-Shun
Fang, Wen-Liang
Lan, Yuan-Tzu
Huang, Kuo-Hung
Li, Anna Fen-Yau
Wu, Chew-Wun
Chen, Jen-Hao
Shyr, Yi-Ming
Chiou, Shih Hwa
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Lymph node metastasis (LNM) in gastric cancer is associated with higher rate of cancer recurrence and poor prognosis.
As a result, a reliable biomarker for the prediction of LNM is important and would be valuable in the clinical practice.
MiRNA microarray revealed that ten miRNAs were expressed significantly different among patients with or without LNM.
A total of 46 gastric cancer patients were enrolled and divided into two groups (23 in each group) according to the presence or absence of LNM.
RT-PCR of these 10 miRNAs was investigated and compared between the two groups.
MiR-1207-5p was significantly upregulated in gastric cancer patients without LNM compared with those with LNM.
Patients with upregulated miR-1207-5p had less scirrhous stromal reaction, less lymphovascular invasion, and earlier pathological T category, N category, and TNM stage, compared with those with downregulated or unchanged miR-1207-5p.
Multivariate analysis showed that stromal reaction type, lymphovascular invasion, pathological T category and TNM stage, and expression of miR-1207-5p were independent risk factors of LNM.
MiR-1207-5p could serve as a useful biomarker in the prediction of LNM in gastric cancer.
American Psychological Association (APA)
Huang, Kuo-Hung& Lan, Yuan-Tzu& Fang, Wen-Liang& Chen, Jen-Hao& Lo, Su-Shun& Li, Anna Fen-Yau…[et al.]. 2015. The Correlation between miRNA and Lymph Node Metastasis in Gastric Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055891
Modern Language Association (MLA)
Huang, Kuo-Hung…[et al.]. The Correlation between miRNA and Lymph Node Metastasis in Gastric Cancer. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1055891
American Medical Association (AMA)
Huang, Kuo-Hung& Lan, Yuan-Tzu& Fang, Wen-Liang& Chen, Jen-Hao& Lo, Su-Shun& Li, Anna Fen-Yau…[et al.]. The Correlation between miRNA and Lymph Node Metastasis in Gastric Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055891
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055891