![](/images/graphics-bg.png)
Serum Vitamin D and Pyridinoline Cross-Linked Carboxyterminal Telopeptide of Type I Collagen in Patients with Ankylosing Spondylitis
Joint Authors
Liao, Zetao
Zhang, Pingping
Li, Qiuxia
Wei, Qiujing
Lin, Zhiming
Fang, Linkai
Gu, Jieruo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To assess the serum vitamin D and ICTP levels in patients with ankylosing spondylitis (AS) and investigate their relationship with disease activity and bone mineral density (BMD).
Method.
150 patients and 168 controls were included.
Serum 25(OH)D, ICTP, C-reaction protein (CRP), Bath AS Disease Activity Index (BASDAI), Bath AS Functional Index (BASFI), and Hip BMD were assessed in patients.
25(OH)D and ICTP were detected in controls.
Results.
The serum 25(OH)D in AS was 57.92 ± 24.42 nmol/L, significantly lower than controls (91.24 ± 42.02 nmol/L).
Serum ICTP in AS was 5.72 ± 3.88 ug/L, significantly higher than controls (3.69 ± 1.26 ug/L).
ICTP level was higher in men than in women patients (6.07 ± 4.05 versus 3.84 ± 1.96 ug/L, P≤0.01); it was also higher in JAS than in AAS (9.52 ± 3.79 versus 5.27 ± 3.65 ug/L, P≤0.01).
Furthermore, 25(OH)D was negatively correlated with ICTP.
Low 25(OH)D and high ICTP were one of the reasons of AS patients’ low hip BMD.
Besides, a significant relationship was found between serum ICTP and CRP.
Conclusion.
There was a high incidence of vitamin D inadequacy in AS.
Serum ICTP level was elevated in AS, especially in JAS and male patients.
25(OH)D and ICTP seem to be valuable markers to detect bone loss in AS.
American Psychological Association (APA)
Zhang, Pingping& Li, Qiuxia& Wei, Qiujing& Liao, Zetao& Lin, Zhiming& Fang, Linkai…[et al.]. 2015. Serum Vitamin D and Pyridinoline Cross-Linked Carboxyterminal Telopeptide of Type I Collagen in Patients with Ankylosing Spondylitis. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055892
Modern Language Association (MLA)
Zhang, Pingping…[et al.]. Serum Vitamin D and Pyridinoline Cross-Linked Carboxyterminal Telopeptide of Type I Collagen in Patients with Ankylosing Spondylitis. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1055892
American Medical Association (AMA)
Zhang, Pingping& Li, Qiuxia& Wei, Qiujing& Liao, Zetao& Lin, Zhiming& Fang, Linkai…[et al.]. Serum Vitamin D and Pyridinoline Cross-Linked Carboxyterminal Telopeptide of Type I Collagen in Patients with Ankylosing Spondylitis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055892
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055892