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Vitamin E Supplementation Delays Cellular Senescence In Vitro
Joint Authors
Mohajeri, M. Hasan
La Fata, Giorgio
Seifert, Nicole
Weber, Peter
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Vitamin E is an important antioxidant that protects cells from oxidative stress-induced damage, which is an important contributor to the progression of ageing.
Ageing can be studied in vitro using primary cells reaching a state of irreversible growth arrest called senescence after a limited number of cellular divisions.
Generally, the most utilized biomarker of senescence is represented by the expression of the senescence associated β-galactosidase (SA-β-gal).
We aimed here to study the possible effects of vitamin E supplementation in two different human primary cell types (HUVECs and fibroblasts) during the progression of cellular senescence.
Utilizing an unbiased automated system, based on the detection of the SA-β-gal, we quantified cellular senescence in vitro and showed that vitamin E supplementation reduced the numbers of senescent cells during progression of ageing.
Acute vitamin E supplementation did not affect cellular proliferation, whereas it was decreased after chronic treatment.
Mechanistically, we show that vitamin E supplementation acts through downregulation of the expression of the cycline dependent kinase inhibitor P21.
The data obtained from this study support the antiageing properties of vitamin E and identify possible mechanisms of action that warrant further investigation.
American Psychological Association (APA)
La Fata, Giorgio& Seifert, Nicole& Weber, Peter& Mohajeri, M. Hasan. 2015. Vitamin E Supplementation Delays Cellular Senescence In Vitro. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055924
Modern Language Association (MLA)
La Fata, Giorgio…[et al.]. Vitamin E Supplementation Delays Cellular Senescence In Vitro. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1055924
American Medical Association (AMA)
La Fata, Giorgio& Seifert, Nicole& Weber, Peter& Mohajeri, M. Hasan. Vitamin E Supplementation Delays Cellular Senescence In Vitro. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055924
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055924