Extraintestinal Helminth Infection Limits Pathology and Proinflammatory Cytokine Expression during DSS-Induced Ulcerative Colitis: A Role for Alternatively Activated Macrophages and Prostaglandins
Joint Authors
Satoskar, Abhay R.
Espinoza-Jiménez, Arlett
Ledesma-Soto, Yadira
Callejas, Blanca E.
Terrazas, César A.
Reyes, Jose L.
González, Marisol I.
Morales, Rosario
Olguín, Jonadab E.
Saavedra, Rafael
Oghumu, Steve
Leon-Cabrera, Sonia
Terrazas, Luis I.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Chronic inflammation of the intestinal mucosa is characteristic of inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease.
Helminth parasites have developed immunomodulatory strategies that may impact the outcome of several inflammatory diseases.
Therefore, we investigated whether Taenia crassiceps infection is able to decrease the inflammatory effects of dextran sulfate sodium- (DSS-) induced ulcerative colitis in BALB/c and C57BL/6 mice.
Preinfection significantly reduced the manifestations of DSS-induced colitis, as weight loss and shortened colon length, and decreased the disease activity index independently of the genetic background of the mice.
Taenia infection decreased systemic levels of proinflammatory cytokines while increasing levels of IL-4 and IL-10, and the inflammatory infiltrate into the colon was also markedly reduced.
RT-PCR assays from colon showed that T.
crassiceps-infected mice displayed increased expression of Arginase-1 but decreased expression of iNOS compared to DSS-treated uninfected mice.
The percentages of T regulatory cells were not increased.
The adoptive transfer of alternatively activated macrophages (AAMФs) from infected mice into mice with DSS-induced colitis reduced the severity of colon inflammation.
Administration of indomethacin abrogated the anticolitic effect of Taenia.
Thus, T.
crassiceps infection limits the pathology of ulcerative colitis by suppressing inflammatory responses mechanistically associated with AAMФs and prostaglandins.
American Psychological Association (APA)
Ledesma-Soto, Yadira& Callejas, Blanca E.& Terrazas, César A.& Reyes, Jose L.& Espinoza-Jiménez, Arlett& González, Marisol I.…[et al.]. 2015. Extraintestinal Helminth Infection Limits Pathology and Proinflammatory Cytokine Expression during DSS-Induced Ulcerative Colitis: A Role for Alternatively Activated Macrophages and Prostaglandins. BioMed Research International،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1055926
Modern Language Association (MLA)
Ledesma-Soto, Yadira…[et al.]. Extraintestinal Helminth Infection Limits Pathology and Proinflammatory Cytokine Expression during DSS-Induced Ulcerative Colitis: A Role for Alternatively Activated Macrophages and Prostaglandins. BioMed Research International No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1055926
American Medical Association (AMA)
Ledesma-Soto, Yadira& Callejas, Blanca E.& Terrazas, César A.& Reyes, Jose L.& Espinoza-Jiménez, Arlett& González, Marisol I.…[et al.]. Extraintestinal Helminth Infection Limits Pathology and Proinflammatory Cytokine Expression during DSS-Induced Ulcerative Colitis: A Role for Alternatively Activated Macrophages and Prostaglandins. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1055926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055926