Influence of Two Common Polymorphisms in the EPHX1 Gene on Warfarin Maintenance Dosage: A Meta-Analysis
Joint Authors
Liu, Hong-Qiang
Zhang, Chang-Po
Zhang, Chang-Zhen
Liu, Xiang-Chen
Liu, Zun-Jing
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
We conducted a meta-analysis to investigate the influence of two common single nucleotide polymorphisms (SNPs) (rs2292566 G>A and rs4653436 A>G) in the EPHX1 gene on warfarin maintenance dosages.
Relevant literatures were searched using the PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, CBM, and CNKI databases without any language restrictions.
STATA Version 12.0 software (Stata Corporation, College Station, TX, USA) was used for this meta-analysis.
Standard mean difference and its corresponding 95% confidence interval (95% CI) were calculated.
Seven studies met the inclusion criteria, including 2,063 warfarin-treated patients.
Meta-analysis results illustrated that EPHX1 rs2292566 G>A polymorphism might be strongly correlated with a higher maintenance dose of warfarin.
However, no interaction of EPHX1 rs4653436 A>G polymorphism with warfarin maintenance dosage was detected.
A further subgroup analysis based on stratification by ethnicity indicated that EPHX1 rs2292566 G>A polymorphism was positively correlated with warfarin maintenance dosage among Caucasians, but not Asians.
No associations were observed between EPHX1 rs4653436 A>G polymorphism warfarin maintenance dosage among both Caucasians and Asians.
Our meta-analysis provides robust and unambiguous evidence that EPHX1 rs2292566 polymorphism may affect the maintenance dose of warfarin in Caucasians.
American Psychological Association (APA)
Liu, Hong-Qiang& Zhang, Chang-Po& Zhang, Chang-Zhen& Liu, Xiang-Chen& Liu, Zun-Jing. 2015. Influence of Two Common Polymorphisms in the EPHX1 Gene on Warfarin Maintenance Dosage: A Meta-Analysis. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055930
Modern Language Association (MLA)
Liu, Hong-Qiang…[et al.]. Influence of Two Common Polymorphisms in the EPHX1 Gene on Warfarin Maintenance Dosage: A Meta-Analysis. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1055930
American Medical Association (AMA)
Liu, Hong-Qiang& Zhang, Chang-Po& Zhang, Chang-Zhen& Liu, Xiang-Chen& Liu, Zun-Jing. Influence of Two Common Polymorphisms in the EPHX1 Gene on Warfarin Maintenance Dosage: A Meta-Analysis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055930
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055930