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In Vitro Activity of Imipenem and Colistin against a Carbapenem-Resistant Klebsiella pneumoniae Isolate Coproducing SHV-31, CMY-2, and DHA-1
Joint Authors
Tang, Hung-Jen
Ku, Yee-Huang
Lee, Mei-Feng
Chuang, Yin-Ching
Yu, Wen-Liang
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We investigated the synergism of colistin and imipenem against a multidrug-resistant K.
pneumoniae isolate which was recovered from a severe hip infection.
PCR and DNA sequencing were used to characterize the outer membrane porin genes and the resistance genes mediating the common β-lactamases and carbapenemases.
Synergism was evaluated by time-kill studies.
The b l a SHV- 31 , b l a CMY-2 , and b l a DHA-1 were detected.
Outer membrane porin genes analysis revealed loss of ompK36 and frame-shift mutation of ompK35.
The common carbapenemase genes were not found.
Time-kill studies demonstrated that a combination of 1x MIC of colistin (2 mg/L) and 1x MIC of imipenem (8 mg/L) was synergistic and bactericidal but with inoculum effect.
Bactericidal activity without inoculum effect was observed by concentration of 2x MIC of colistin alone or plus 2x MIC of imipenem.
In conclusion, colistin plus imipenem could be an alternative option to treat carbapenem-resistant K.
pneumoniae infections.
American Psychological Association (APA)
Tang, Hung-Jen& Ku, Yee-Huang& Lee, Mei-Feng& Chuang, Yin-Ching& Yu, Wen-Liang. 2015. In Vitro Activity of Imipenem and Colistin against a Carbapenem-Resistant Klebsiella pneumoniae Isolate Coproducing SHV-31, CMY-2, and DHA-1. BioMed Research International،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1055939
Modern Language Association (MLA)
Tang, Hung-Jen…[et al.]. In Vitro Activity of Imipenem and Colistin against a Carbapenem-Resistant Klebsiella pneumoniae Isolate Coproducing SHV-31, CMY-2, and DHA-1. BioMed Research International No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1055939
American Medical Association (AMA)
Tang, Hung-Jen& Ku, Yee-Huang& Lee, Mei-Feng& Chuang, Yin-Ching& Yu, Wen-Liang. In Vitro Activity of Imipenem and Colistin against a Carbapenem-Resistant Klebsiella pneumoniae Isolate Coproducing SHV-31, CMY-2, and DHA-1. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1055939
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055939