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Multicontrast MRI Quantification of Focal Inflammation and Degeneration in Multiple Sclerosis
Joint Authors
Du Pasquier, R.
Frahm, Jens
Bonnier, Guillaume
Roche, Alexis
Romascano, David
Simioni, Samanta
Meskaldji, Djalel Eddine
Rotzinger, David
Lin, Ying-Chia
Menegaz, Gloria
Schluep, Myriam
Sumpf, Tilman Johannes
Thiran, Jean-Philippe
Krueger, Gunnar
Granziera, Cristina
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Introduction.
Local microstructural pathology in multiple sclerosis patients might influence their clinical performance.
This study applied multicontrast MRI to quantify inflammation and neurodegeneration in MS lesions.
We explored the impact of MRI-based lesion pathology in cognition and disability.
Methods.
36 relapsing-remitting MS subjects and 18 healthy controls underwent neurological, cognitive, behavioural examinations and 3 T MRI including (i) fluid attenuated inversion recovery, double inversion recovery, and magnetization-prepared gradient echo for lesion count; (ii) T1, T2, and T2* relaxometry and magnetisation transfer imaging for lesion tissue characterization.
Lesions were classified according to the extent of inflammation/neurodegeneration.
A generalized linear model assessed the contribution of lesion groups to clinical performances.
Results.
Four lesion groups were identified and characterized by (1) absence of significant alterations, (2) prevalent inflammation, (3) concomitant inflammation and microdegeneration, and (4) prevalent tissue loss.
Groups 1, 3, 4 correlated with general disability (Adj-R2=0.6; P=0.0005), executive function (Adj-R2=0.5; P=0.004), verbal memory (Adj-R2=0.4; P=0.02), and attention (Adj-R2=0.5; P=0.002).
Conclusion.
Multicontrast MRI provides a new approach to infer in vivo histopathology of plaques.
Our results support evidence that neurodegeneration is the major determinant of patients’ disability and cognitive dysfunction.
American Psychological Association (APA)
Bonnier, Guillaume& Roche, Alexis& Romascano, David& Simioni, Samanta& Meskaldji, Djalel Eddine& Rotzinger, David…[et al.]. 2015. Multicontrast MRI Quantification of Focal Inflammation and Degeneration in Multiple Sclerosis. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055945
Modern Language Association (MLA)
Bonnier, Guillaume…[et al.]. Multicontrast MRI Quantification of Focal Inflammation and Degeneration in Multiple Sclerosis. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055945
American Medical Association (AMA)
Bonnier, Guillaume& Roche, Alexis& Romascano, David& Simioni, Samanta& Meskaldji, Djalel Eddine& Rotzinger, David…[et al.]. Multicontrast MRI Quantification of Focal Inflammation and Degeneration in Multiple Sclerosis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055945
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055945