Prokinetic Activity of Prunus persica (L.) Batsch Flowers Extract and Its Possible Mechanism of Action in Rats
Joint Authors
Han, Wei
Xu, Jing Dong
Wei, Feng Xian
Zheng, Yong Dong
Ma, Jian Zhong
Xu, Xiao Dong
Wei, Zhen Gang
Wang, Wen
Zhang, You Cheng
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The peach tree, Prunus persica (L.) Batsch, is widely cultivated in China, and its flowers have been used for centuries in traditional Chinese medicine to treat gut motility disorders.
But few studies have explored the pharmacological effect of Prunus persica (L.) Batsch flowers on gastrointestinal motility.
In this study, the activities of different extracts from Prunus persica (L.) Batsch flowers on the smooth muscle contractions were evaluated using isolated colon model, and the ethyl acetate extract (EAE) showed the strongest effects in vitro.
EAE (10−8–10−5 g/mL) caused a concentration-dependent stimulatory effect in rat colonic tissue.
Additionally, ketotifen (100 µM), cimetidine (10 µM), and pyrilamine (1 µM) produced a significant inhibition of contractions caused by EAE.
Furthermore, immunofluorescence and toluidine blue staining revealed increased numbers of mast cells in the EAE group, and EAE increased histamine release from the colonic tissues.
These data indicate that EAE has significant prokinetic activity and acts by a mechanism that mainly involves mast cell degranulation.
Our study provides a pharmacological basis for the use of an extract of Prunus persica (L.) Batsch flowers in the treatment of gut motility disorders.
American Psychological Association (APA)
Han, Wei& Xu, Jing Dong& Wei, Feng Xian& Zheng, Yong Dong& Ma, Jian Zhong& Xu, Xiao Dong…[et al.]. 2015. Prokinetic Activity of Prunus persica (L.) Batsch Flowers Extract and Its Possible Mechanism of Action in Rats. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055949
Modern Language Association (MLA)
Han, Wei…[et al.]. Prokinetic Activity of Prunus persica (L.) Batsch Flowers Extract and Its Possible Mechanism of Action in Rats. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1055949
American Medical Association (AMA)
Han, Wei& Xu, Jing Dong& Wei, Feng Xian& Zheng, Yong Dong& Ma, Jian Zhong& Xu, Xiao Dong…[et al.]. Prokinetic Activity of Prunus persica (L.) Batsch Flowers Extract and Its Possible Mechanism of Action in Rats. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055949
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055949