Can Variability of Pattern ERG Signal Help to Detect Retinal Ganglion Cells Dysfunction in Glaucomatous Eyes?
Joint Authors
Mavilio, Alberto
Scrimieri, Francesca
Errico, Donato
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
To evaluate variability of steady-state pattern electroretinogram (SS-PERG) signal in normal, suspected, and glaucomatous eyes.
Methods.
Twenty-one subjects with suspected glaucoma due to disc abnormalities (GS), 37 patients with early glaucoma (EG), and 24 normal control (NC) were tested with spectral-domain optical coherence tomography (SD-OCT), standard automated perimetry (SAP), and SS-PERG.
Mean deviation (MD), pattern standard deviation (PSD), retinal nerve fiber layer (RNFL), and ganglionar complex cells (GCC) were evaluated.
The SS-PERG was recorded five consecutive times and the amplitude and phase of second harmonic were measured.
PERG amplitude and coefficient of variation of phase (CVphase) were recorded, and correlation with structural and functional parameters of disease, by means of one-way ANOVA and Pearson’s correlation, was analysed.
Results.
PERG amplitude was reduced, as expression of retinal ganglion cells (RGCs) dysfunction, in EG patients and GS subjects compared to NC patients ( P < 0.0001 ).
CVphase was significantly increased in EG patients and GS subjects, compared to healthy ( P < 0.0001 ), and it was also correlated with PSD ( P = 0.0009 ), GCC ( P = 0.028 ), and RNFL ( P = 0.0078 ) only in EG patients.
Conclusions.
Increased intrasession variability of phase in suspected glaucomatous eyes may be a sign of RGCs dysfunction.
American Psychological Association (APA)
Mavilio, Alberto& Scrimieri, Francesca& Errico, Donato. 2015. Can Variability of Pattern ERG Signal Help to Detect Retinal Ganglion Cells Dysfunction in Glaucomatous Eyes?. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055955
Modern Language Association (MLA)
Mavilio, Alberto…[et al.]. Can Variability of Pattern ERG Signal Help to Detect Retinal Ganglion Cells Dysfunction in Glaucomatous Eyes?. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1055955
American Medical Association (AMA)
Mavilio, Alberto& Scrimieri, Francesca& Errico, Donato. Can Variability of Pattern ERG Signal Help to Detect Retinal Ganglion Cells Dysfunction in Glaucomatous Eyes?. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055955
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055955