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MRI-Targeted Biopsies versus Systematic Transrectal Ultrasound Guided Biopsies for the Diagnosis of Localized Prostate Cancer in Biopsy Naïve Men
Joint Authors
Peltier, Alexandre
Paesmans, Marianne
Lemort, Marc
Kwizera, Félix
van Velthoven, Roland
Aoun, Fouad
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
To compare, in the same cohort of men, the detection of clinically significant disease in standard (STD) cores versus multiparametric magnetic resonance imaging (mpMRI) targeted (TAR) cores.
Material and Methods.
A prospective study was conducted on 129 biopsy naïve men with clinical suspicion of prostate cancer.
These patients underwent prebiopsy mpMRI with STD systematic biopsies and TAR biopsies when lesions were found.
The agreement between the TAR and the STD protocols was measured using Cohen’s kappa coefficient.
Results.
Cancer detection rate of MRI-targeted biopsy was 62.7%.
TAR protocol demonstrated higher detection rate of clinically significant disease compared to STD protocol.
The proportion of cores positive for clinically significant cancer in TAR cores was 28.9% versus 9.8% for STD cores (P<0.001).
The proportion of men with clinically significant cancer and the proportion of men with Gleason score 7 were higher with the TAR protocol than with the STD protocol (P=0.003; P=0.0008, resp.).
Conclusion.
mpMRI improved clinically significant prostate cancer detection rate compared to STD protocol alone with less tissue sampling and higher Gleason score.
Further development in imaging as well as multicentre studies using the START recommendation is needed to elucidate the role of mpMRI targeted biopsy in the management of prostate cancer.
American Psychological Association (APA)
Peltier, Alexandre& Aoun, Fouad& Lemort, Marc& Kwizera, Félix& Paesmans, Marianne& van Velthoven, Roland. 2015. MRI-Targeted Biopsies versus Systematic Transrectal Ultrasound Guided Biopsies for the Diagnosis of Localized Prostate Cancer in Biopsy Naïve Men. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055957
Modern Language Association (MLA)
Peltier, Alexandre…[et al.]. MRI-Targeted Biopsies versus Systematic Transrectal Ultrasound Guided Biopsies for the Diagnosis of Localized Prostate Cancer in Biopsy Naïve Men. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1055957
American Medical Association (AMA)
Peltier, Alexandre& Aoun, Fouad& Lemort, Marc& Kwizera, Félix& Paesmans, Marianne& van Velthoven, Roland. MRI-Targeted Biopsies versus Systematic Transrectal Ultrasound Guided Biopsies for the Diagnosis of Localized Prostate Cancer in Biopsy Naïve Men. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055957
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055957