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Using PETCT Bone Scan Dynamic Data to Evaluate Tibia Remodeling When a Taylor Spatial Frame Is Used: Short and Longer Term Differences
Joint Authors
Weidenhielm, Lars
Lundblad, Henrik
Maguire, Gerald Q.
Jonsson, Cathrine
Jacobsson, Hans
Zeleznik, Michael P.
Karlsson-Thur, Charlotte
Noz, Marilyn E.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Eighteen consecutive patients, treated with a Taylor Spatial Frame for complex tibia conditions, gave their informed consent to undergo Na18F− PET/CT bone scans.
We present a Patlak-like analysis utilizing an approximated blood time-activity curve eliminating the need for blood aliquots.
Additionally, standardized uptake values (SUV) derived from dynamic acquisitions were compared to this Patlak-like approach.
Spherical volumes of interest (VOIs) were drawn to include broken bone, other (normal) bone, and muscle.
The SUV m ( t ) ( m = m a x , mean) and a series of slopes were computed as ( SUV m ( t i ) - SUV m ( t j ) ) / ( t i - t j ) , for pairs of time values t i and t j .
A Patlak-like analysis was performed for the same time values by computing ( ( VOI p ( t i ) / VOI e ( t i ) ) - ( VOI p ( t j ) / VOI e ( t j ) ) ) / ( t i - t j ) , where p = broken bone, other bone, and muscle and e = expected activity in a VOI.
Paired comparisons between Patlak-like and SUV m slopes showed good agreement by both linear regression and correlation coefficient analysis ( r = 84 % , r s = 78 % - SUV max , r = 92 % , and r s = 91 % - SUV mean ), suggesting static scans could substitute for dynamic studies.
Patlak-like slope differences of 0.1 min−1 or greater between examinations and SU V max differences of ~5 usually indicated good remodeling progress, while negative Patlak-like slope differences of −0.06 min−1 usually indicated poor remodeling progress in this cohort.
American Psychological Association (APA)
Lundblad, Henrik& Maguire, Gerald Q.& Karlsson-Thur, Charlotte& Jonsson, Cathrine& Noz, Marilyn E.& Zeleznik, Michael P.…[et al.]. 2015. Using PETCT Bone Scan Dynamic Data to Evaluate Tibia Remodeling When a Taylor Spatial Frame Is Used: Short and Longer Term Differences. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055971
Modern Language Association (MLA)
Lundblad, Henrik…[et al.]. Using PETCT Bone Scan Dynamic Data to Evaluate Tibia Remodeling When a Taylor Spatial Frame Is Used: Short and Longer Term Differences. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1055971
American Medical Association (AMA)
Lundblad, Henrik& Maguire, Gerald Q.& Karlsson-Thur, Charlotte& Jonsson, Cathrine& Noz, Marilyn E.& Zeleznik, Michael P.…[et al.]. Using PETCT Bone Scan Dynamic Data to Evaluate Tibia Remodeling When a Taylor Spatial Frame Is Used: Short and Longer Term Differences. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055971
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055971