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Nonalcoholic Steatohepatitis: A Search for Factual Animal Models
Joint Authors
Ramalho, Leandra Naira Zambelli
Sanches, Sheila Cristina L.
Augusto, Marlei Josiele
da Silva, Deisy Mara
Ramalho, Fernando S.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-03
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, which occurs in the absence of alcohol abuse.
NAFLD can evolve into progressive liver injury and fibrosis in the form of nonalcoholic steatohepatitis (NASH).
Several animal models have been developed to attempt to represent the morphological, biochemical, and clinical features of human NASH.
The actual review presents a critical analysis of the most commonly used experimental models of NAFLD/NASH development.
These models can be classified into genetic, nutritional, and a combination of genetic and nutritional factors.
The main genetic models are ob/ob and db/db mutant mice and Zucker rats.
The principal nutritional models employ methionine- and choline-deficient, high-fat, high-cholesterol and high-cholate, cafeteria, and high-fructose diets.
Currently, associations between high-fructose and various compositions of high-fat diets have been widely studied.
Previous studies have encountered significant difficulties in developing animal models capable of reproducing human NASH.
Some models produce consistent morphological findings, but the induction method differs significantly compared with the pathophysiology of human NASH.
Other models precisely represent the clinical and etiological contexts of this disease but fail to provide accurate histopathological representations mainly in the progression from steatosis to liver fibrosis.
American Psychological Association (APA)
Sanches, Sheila Cristina L.& Ramalho, Leandra Naira Zambelli& Augusto, Marlei Josiele& da Silva, Deisy Mara& Ramalho, Fernando S.. 2015. Nonalcoholic Steatohepatitis: A Search for Factual Animal Models. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055972
Modern Language Association (MLA)
Sanches, Sheila Cristina L.…[et al.]. Nonalcoholic Steatohepatitis: A Search for Factual Animal Models. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1055972
American Medical Association (AMA)
Sanches, Sheila Cristina L.& Ramalho, Leandra Naira Zambelli& Augusto, Marlei Josiele& da Silva, Deisy Mara& Ramalho, Fernando S.. Nonalcoholic Steatohepatitis: A Search for Factual Animal Models. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055972
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055972