TTBK2: A Tau Protein Kinase beyond Tau Phosphorylation
Joint Authors
Liao, Jung-Chi
Yang, T. Tony
Weng, Rueyhung Roc
Kuo, Ching-Te
Chang, Chih-Wei
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Tau tubulin kinase 2 (TTBK2) is a kinase known to phosphorylate tau and tubulin.
It has recently drawn much attention due to its involvement in multiple important cellular processes.
Here, we review the current understanding of TTBK2, including its sequence, structure, binding sites, phosphorylation substrates, and cellular processes involved.
TTBK2 possesses a casein kinase 1 (CK1) kinase domain followed by a ~900 amino acid segment, potentially responsible for its localization and substrate recruitment.
It is known to bind to CEP164, a centriolar protein, and EB1, a microtubule plus-end tracking protein.
In addition to autophosphorylation, known phosphorylation substrates of TTBK2 include tau, tubulin, CEP164, CEP97, and TDP-43, a neurodegeneration-associated protein.
Mutations of TTBK2 are associated with spinocerebellar ataxia type 11.
In addition, TTBK2 is essential for regulating the growth of axonemal microtubules in ciliogenesis.
It also plays roles in resistance of cancer target therapies and in regulating glucose and GABA transport.
Reported sites of TTBK2 localization include the centriole/basal body, the midbody, and possibly the mitotic spindles.
Together, TTBK2 is a multifunctional kinase involved in important cellular processes and demands augmented efforts in investigating its functions.
American Psychological Association (APA)
Liao, Jung-Chi& Yang, T. Tony& Weng, Rueyhung Roc& Kuo, Ching-Te& Chang, Chih-Wei. 2015. TTBK2: A Tau Protein Kinase beyond Tau Phosphorylation. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055975
Modern Language Association (MLA)
Liao, Jung-Chi…[et al.]. TTBK2: A Tau Protein Kinase beyond Tau Phosphorylation. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1055975
American Medical Association (AMA)
Liao, Jung-Chi& Yang, T. Tony& Weng, Rueyhung Roc& Kuo, Ching-Te& Chang, Chih-Wei. TTBK2: A Tau Protein Kinase beyond Tau Phosphorylation. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055975
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055975