CollagenBeta-Tricalcium Phosphate Based Synthetic Bone Grafts via Dehydrothermal Processing
Joint Authors
Sarikaya, Burcu
Aydin, Halil Murat
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Millions of patients worldwide remain inadequately treated for bone defects related to factors such as disease or trauma.
The drawbacks of metallic implant and autograft/allograft use have steered therapeutic approaches towards tissue engineering solutions involving tissue regeneration scaffolds.
This study proposes a composite scaffold with properties tailored to address the macro- and microenvironmental conditions deemed necessary for successful regeneration of bone in defect areas.
The biodegradable scaffold composed of porous beta-tricalcium phosphate particles and collagen type I fibers is prepared from a mixture of collagen type-I and β-tricalcium phosphate (β-TCP) particles via lyophilization, followed by dehydrothermal (DHT) processing.
The effects of both sterilization via gamma radiation and the use of DHT processing to achieve cross-linking were investigated.
The impact of the chosen fabrication methods on scaffold microstructure and β-TCP particle-collagen fiber combinations were analyzed using X-ray diffractometry (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and microcomputerized tomography (µ-CT).
Electron spinning resonance (ESR) analysis was used to investigate free radicals formation following sterilization.
Results revealed that the highly porous (65% porosity at an average of 100 µm pore size), mechanically adequate, and biocompatible scaffolds can be utilized for bone defect repairs.
American Psychological Association (APA)
Sarikaya, Burcu& Aydin, Halil Murat. 2015. CollagenBeta-Tricalcium Phosphate Based Synthetic Bone Grafts via Dehydrothermal Processing. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055982
Modern Language Association (MLA)
Sarikaya, Burcu& Aydin, Halil Murat. CollagenBeta-Tricalcium Phosphate Based Synthetic Bone Grafts via Dehydrothermal Processing. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055982
American Medical Association (AMA)
Sarikaya, Burcu& Aydin, Halil Murat. CollagenBeta-Tricalcium Phosphate Based Synthetic Bone Grafts via Dehydrothermal Processing. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055982
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055982