The Potential Role of NFAT5 and Osmolarity in Peritoneal Injury

Joint Authors

Alscher, Mark Dominik
Seeger, Harald
Kitterer, Daniel
Braun, Niko
Segerer, Stephan
Latus, Joerg

Source

BioMed Research International

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-09-30

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Medicine

Abstract EN

A rise in osmotic concentration (osmolarity) activates the transcription factor Nuclear Factor of Activated T Cells 5 (NFAT5, also known as Tonicity-responsive Enhancer Binding Protein, TonEBP).

This is part of a regulatory mechanism of cells adjusting to environments of high osmolarity.

Under physiological conditions these are particularly important in the kidney.

Activation of NFAT5 results in the modulation of various genes including some which promote inflammation.

The osmolarity increases in patients with renal failure.

Additionally, in peritoneal dialysis the cells of the peritoneal cavity are repeatedly exposed to a rise and fall in osmotic concentrations.

Here we review the current information about NFAT5 activation in uremic patients and patients on peritoneal dialysis.

We suggest that high osmolarity promotes injury in the “uremic” milieu, which results in inflammation locally in the peritoneal membrane, but most likely also in the systemic circulation.

American Psychological Association (APA)

Seeger, Harald& Kitterer, Daniel& Latus, Joerg& Alscher, Mark Dominik& Braun, Niko& Segerer, Stephan. 2015. The Potential Role of NFAT5 and Osmolarity in Peritoneal Injury. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055986

Modern Language Association (MLA)

Seeger, Harald…[et al.]. The Potential Role of NFAT5 and Osmolarity in Peritoneal Injury. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1055986

American Medical Association (AMA)

Seeger, Harald& Kitterer, Daniel& Latus, Joerg& Alscher, Mark Dominik& Braun, Niko& Segerer, Stephan. The Potential Role of NFAT5 and Osmolarity in Peritoneal Injury. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055986

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1055986