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The Potential Role of NFAT5 and Osmolarity in Peritoneal Injury
Joint Authors
Alscher, Mark Dominik
Seeger, Harald
Kitterer, Daniel
Braun, Niko
Segerer, Stephan
Latus, Joerg
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A rise in osmotic concentration (osmolarity) activates the transcription factor Nuclear Factor of Activated T Cells 5 (NFAT5, also known as Tonicity-responsive Enhancer Binding Protein, TonEBP).
This is part of a regulatory mechanism of cells adjusting to environments of high osmolarity.
Under physiological conditions these are particularly important in the kidney.
Activation of NFAT5 results in the modulation of various genes including some which promote inflammation.
The osmolarity increases in patients with renal failure.
Additionally, in peritoneal dialysis the cells of the peritoneal cavity are repeatedly exposed to a rise and fall in osmotic concentrations.
Here we review the current information about NFAT5 activation in uremic patients and patients on peritoneal dialysis.
We suggest that high osmolarity promotes injury in the “uremic” milieu, which results in inflammation locally in the peritoneal membrane, but most likely also in the systemic circulation.
American Psychological Association (APA)
Seeger, Harald& Kitterer, Daniel& Latus, Joerg& Alscher, Mark Dominik& Braun, Niko& Segerer, Stephan. 2015. The Potential Role of NFAT5 and Osmolarity in Peritoneal Injury. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055986
Modern Language Association (MLA)
Seeger, Harald…[et al.]. The Potential Role of NFAT5 and Osmolarity in Peritoneal Injury. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1055986
American Medical Association (AMA)
Seeger, Harald& Kitterer, Daniel& Latus, Joerg& Alscher, Mark Dominik& Braun, Niko& Segerer, Stephan. The Potential Role of NFAT5 and Osmolarity in Peritoneal Injury. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055986
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055986