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Design and Synthesis of a Novel Cationic Peptide with Potent and Broad-Spectrum Antimicrobial Activity
Joint Authors
Liu, Wen-Ping
Chen, Ya-Hui
Ming, Xin
Kong, Yi
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Antibacterial and antifungal peptides have increasingly been used to combat the antibiotic-resistant microbes in recent years.
KW-13, a novel cationic α-helical antibacterial peptide consisting of 13 amino acid residues, was designed and chemically synthesized.
The peptide has a net charge of +6 with a total hydrophobic ratio of 38%.
The antibacterial experiments revealed that KW-13 strongly inhibited the growth of human pathogenic bacteria with minimal inhibitory concentrations of 4 and 16 μg/mL for Staphylococcus epidermidis and Staphylococcus aureus, respectively, while the hemolytic assay showed that this peptide did not destroy human red blood cells in vitro.
Scanning electron microscopy imaging of Escherichia coli confirmed that KW-13 can damage the membrane of bacterial cells.
Thus, this peptide could be a potential candidate for the treatment of infectious diseases.
American Psychological Association (APA)
Liu, Wen-Ping& Chen, Ya-Hui& Ming, Xin& Kong, Yi. 2015. Design and Synthesis of a Novel Cationic Peptide with Potent and Broad-Spectrum Antimicrobial Activity. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055987
Modern Language Association (MLA)
Liu, Wen-Ping…[et al.]. Design and Synthesis of a Novel Cationic Peptide with Potent and Broad-Spectrum Antimicrobial Activity. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1055987
American Medical Association (AMA)
Liu, Wen-Ping& Chen, Ya-Hui& Ming, Xin& Kong, Yi. Design and Synthesis of a Novel Cationic Peptide with Potent and Broad-Spectrum Antimicrobial Activity. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055987
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055987