A New Approach Using Manganese-Enhanced MRI to Diagnose Acute Mesenteric Ischemia in a Rabbit Model: Initial Experience
Joint Authors
Zhao, Da-wei
Cheng, Cheng
Kuang, Lian-qin
Zhang, Yu-long
Cheng, Hai-yun
Min, Jia-yan
Wang, Yi
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
Manganese-enhanced MRI (MEMRI) has been applied to a wide range of biological and disease research.
The purpose of the study was to use MEMRI to diagnose the acute mesenteric ischemia (AMI).
Methods.
The institutional experimental animal ethics committee approved this study.
To optimize the dose of Mn2+ infusion, a dose-dependent curve was obtained using Mn2+-enhanced T 1 map MRI by an intravenous infusion 2.5–20 nmol/g body weight (BW) of 50 nmol/L MnCl2.
The eighteen animals were divided into control, sham-operated, and AMI groups.
AMI models were performed by ligating the superior mesenteric artery (SMA).
T 1 values were measured on T 1 maps in regions of the small intestinal wall and relaxation rate (ΔR 1) was calculated.
Results.
A nonlinear relationship between infused MnCl2 solution dose and increase in small intestinal wall ΔR 1 was observed.
Control animal exhibited significant Mn2+ clearance over time at the dose of 15 nmol/g BW.
In the AMI model, ΔR 1 values (0.95 ± 0.13) in the small intestinal wall were significantly lower than in control group (2.05 ± 0.19) after Mn2+ infusion (P < 0.01).
Conclusion.
The data suggest that MEMRI shows potential as a diagnostic technique that is directly sensitive to the poor or absent perfusion in AMI.
American Psychological Association (APA)
Zhao, Da-wei& Cheng, Cheng& Kuang, Lian-qin& Zhang, Yu-long& Cheng, Hai-yun& Min, Jia-yan…[et al.]. 2015. A New Approach Using Manganese-Enhanced MRI to Diagnose Acute Mesenteric Ischemia in a Rabbit Model: Initial Experience. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055991
Modern Language Association (MLA)
Zhao, Da-wei…[et al.]. A New Approach Using Manganese-Enhanced MRI to Diagnose Acute Mesenteric Ischemia in a Rabbit Model: Initial Experience. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1055991
American Medical Association (AMA)
Zhao, Da-wei& Cheng, Cheng& Kuang, Lian-qin& Zhang, Yu-long& Cheng, Hai-yun& Min, Jia-yan…[et al.]. A New Approach Using Manganese-Enhanced MRI to Diagnose Acute Mesenteric Ischemia in a Rabbit Model: Initial Experience. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055991
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055991