Direct Cardiac Reprogramming: Advances in Cardiac Regeneration
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Heart disease is one of the lead causes of death worldwide.
Many forms of heart disease, including myocardial infarction and pressure-loading cardiomyopathies, result in irreversible cardiomyocyte death.
Activated fibroblasts respond to cardiac injury by forming scar tissue, but ultimately this response fails to restore cardiac function.
Unfortunately, the human heart has little regenerative ability and long-term outcomes following acute coronary events often include chronic and end-stage heart failure.
Building upon years of research aimed at restoring functional cardiomyocytes, recent advances have been made in the direct reprogramming of fibroblasts toward a cardiomyocyte cell fate both in vitro and in vivo.
Several experiments show functional improvements in mouse models of myocardial infarction following in situ generation of cardiomyocyte-like cells from endogenous fibroblasts.
Though many of these studies are in an early stage, this nascent technology holds promise for future applications in regenerative medicine.
In this review, we discuss the history, progress, methods, challenges, and future directions of direct cardiac reprogramming.
American Psychological Association (APA)
Chen, Olivia& Qian, Li. 2015. Direct Cardiac Reprogramming: Advances in Cardiac Regeneration. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055994
Modern Language Association (MLA)
Chen, Olivia& Qian, Li. Direct Cardiac Reprogramming: Advances in Cardiac Regeneration. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055994
American Medical Association (AMA)
Chen, Olivia& Qian, Li. Direct Cardiac Reprogramming: Advances in Cardiac Regeneration. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055994
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055994