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Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer
Joint Authors
Li, Dong
Hao, Shu-Hong
Sun, Yan
Hu, Chun-Mei
Ma, Zhi-Hua
Wang, Zhi Ming
Liu, Jie
Liu, Hong Bo
Ye, Ming
Zhang, Yu Fei
Yang, Dong Sheng
Shi, Guang
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
This meta-analysis investigated the association between functional COX-2 gene polymorphisms and the risk of oral cancer.
Methods.
Several electronic databases were searched for published studies using combinations of keywords related to COX-2 gene polymorphisms and oral cancer.
After selection of relevant studies, following strict inclusion and exclusion criteria, data was performed using STATA 12.0 software.
Results.
We retrieved 83 studies from database search using specific search terms.
After multiple rounds of selection and elimination, 7 studies were finally identified as suitable to be included in our present meta-analysis, based on their relevance and data integrity.
These 7 studies contained a combined total of 2,296 oral cancer patients and 3,647 healthy controls.
Our findings demonstrated that +837 T > C (rs5275) polymorphism in COX-2 showed statistically significant differences in gene frequencies in case and control groups in allele model and dominant model.
Similar results were obtained with COX-2 gene polymorphism 765 G > C (rs20417).
On the other hand, 1195 A > G (rs689466) polymorphism in COX-2 did not confer susceptibility to oral cancers.
Conclusion.
Based on our results, COX-2 gene polymorphisms, +837 T > C (rs5275) and −765G > C (rs20417), showed clear links with oral cancer susceptibility, and the 1195A > G (rs689466) polymorphism did not show such a correlation.
American Psychological Association (APA)
Li, Dong& Hao, Shu-Hong& Sun, Yan& Hu, Chun-Mei& Ma, Zhi-Hua& Wang, Zhi Ming…[et al.]. 2015. Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055996
Modern Language Association (MLA)
Li, Dong…[et al.]. Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1055996
American Medical Association (AMA)
Li, Dong& Hao, Shu-Hong& Sun, Yan& Hu, Chun-Mei& Ma, Zhi-Hua& Wang, Zhi Ming…[et al.]. Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055996
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055996