Comprehensive Review on Betulin as a Potent Anticancer Agent
Joint Authors
Król, Sylwia Katarzyna
Kiełbus, Michał
Stepulak, Andrzej
Rivero-Müller, Adolfo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Numerous plant-derived substances, and their derivatives, are effective antitumour and chemopreventive agents.
Yet, there are also a plethora of tumour types that do not respond, or become resistant, to these natural substances.
This requires the discovery of new active compounds.
Betulin (BE) is a pentacyclic triterpene and secondary metabolite of plants abundantly found in the outer bark of the birch tree Betulaceae sp.
BE displays a broad spectrum of biological and pharmacological properties, among which the anticancer and chemopreventive activity attract most of the attention.
In this vein, BE and its natural and synthetic derivatives act specifically on cancer cells with low cytotoxicity towards normal cells.
Although the antineoplastic mechanism of action of BE is not well understood yet, several interesting aspects of BE’s interactions are coming to light.
This review will summarize the anticancer and chemopreventive potential of BE in vitro and in vivo by carefully dissecting and comparing the doses and tumour lines used in previous studies, as well as focusing on mechanisms underlying its activity at cellular and molecular level, and discuss future prospects.
American Psychological Association (APA)
Król, Sylwia Katarzyna& Kiełbus, Michał& Rivero-Müller, Adolfo& Stepulak, Andrzej. 2015. Comprehensive Review on Betulin as a Potent Anticancer Agent. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056009
Modern Language Association (MLA)
Król, Sylwia Katarzyna…[et al.]. Comprehensive Review on Betulin as a Potent Anticancer Agent. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1056009
American Medical Association (AMA)
Król, Sylwia Katarzyna& Kiełbus, Michał& Rivero-Müller, Adolfo& Stepulak, Andrzej. Comprehensive Review on Betulin as a Potent Anticancer Agent. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056009
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056009